Inflammatory lung diseases are highly complex in respect of pathogenesis and relationships
between inflammation, clinical disease and response to treatment. Sophisticated large-…

Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for
SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the …

Rationale: Stratification of asthma at the molecular level, especially using accessible
biospecimens, could greatly enable patient selection for targeted therapy. Objectives: To determine …

Background The role of IL-17 immunity is well established in patients with inflammatory
diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in …

Background Stratification by eosinophil and neutrophil counts increases our understanding
of asthma and helps target therapy, but there is room for improvement in our accuracy in …

Background Growing evidence indicates high comorbid anxiety and depression in patients
with asthma. However, the mechanisms underlying this comorbid condition remain unclear. …

Idiopathic pulmonary fibrosis (IPF) is a progressive disease that usually affects elderly people.
It has a poor prognosis and there are limited therapies. Since epigenetic alterations are …

Pseudomonas aeruginosa MPAO1 is the parental strain of the widely utilized transposon
mutant collection for this important clinical pathogen. Here, we validate a model system to …

Current experimental vaccines against serogroup B Neisseria meningitidis are based on
meningococcal outer membrane (OM) proteins present in outer membrane vesicles (OMV) in …

Ocean acidification due to rising atmospheric CO 2 is expected to affect the physiology of
important calcifying marine organisms, but the nature and magnitude of change is yet to be …