User profiles for Paul J. Skipp
Paul SkippProfessor of Proteomics, University of Southampton Verified email at soton.ac.uk Cited by 3644 |
Application of'omics technologies to biomarker discovery in inflammatory lung diseases
…, B Nicholas, J Brandsma, PJ Skipp… - European …, 2013 - Eur Respiratory Soc
Inflammatory lung diseases are highly complex in respect of pathogenesis and relationships
between inflammation, clinical disease and response to treatment. Sophisticated large-…
between inflammation, clinical disease and response to treatment. Sophisticated large-…
[HTML][HTML] A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection
Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for
SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the …
SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the …
A severe asthma disease signature from gene expression profiling of peripheral blood from U-BIOPRED cohorts
…, JPR Schofield, PJ Skipp, J Corfield… - American journal of …, 2017 - atsjournals.org
Rationale: Stratification of asthma at the molecular level, especially using accessible
biospecimens, could greatly enable patient selection for targeted therapy. Objectives: To determine …
biospecimens, could greatly enable patient selection for targeted therapy. Objectives: To determine …
IL-17–high asthma with features of a psoriasis immunophenotype
Background The role of IL-17 immunity is well established in patients with inflammatory
diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in …
diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in …
Stratification of asthma phenotypes by airway proteomic signatures
Background Stratification by eosinophil and neutrophil counts increases our understanding
of asthma and helps target therapy, but there is room for improvement in our accuracy in …
of asthma and helps target therapy, but there is room for improvement in our accuracy in …
[HTML][HTML] The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
Background Growing evidence indicates high comorbid anxiety and depression in patients
with asthma. However, the mechanisms underlying this comorbid condition remain unclear. …
with asthma. However, the mechanisms underlying this comorbid condition remain unclear. …
[HTML][HTML] The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive disease that usually affects elderly people.
It has a poor prognosis and there are limited therapies. Since epigenetic alterations are …
It has a poor prognosis and there are limited therapies. Since epigenetic alterations are …
[HTML][HTML] An integrated model system to gain mechanistic insights into biofilm-associated antimicrobial resistance in Pseudomonas aeruginosa MPAO1
Pseudomonas aeruginosa MPAO1 is the parental strain of the widely utilized transposon
mutant collection for this important clinical pathogen. Here, we validate a model system to …
mutant collection for this important clinical pathogen. Here, we validate a model system to …
Proteomic Analysis of Outer Membranes and Vesicles from Wild-Type Serogroup B Neisseria meningitidis and a Lipopolysaccharide-Deficient Mutant
JN Williams, PJ Skipp, HE Humphries… - Infection and …, 2007 - Am Soc Microbiol
Current experimental vaccines against serogroup B Neisseria meningitidis are based on
meningococcal outer membrane (OM) proteins present in outer membrane vesicles (OMV) in …
meningococcal outer membrane (OM) proteins present in outer membrane vesicles (OMV) in …
[HTML][HTML] Responses of the Emiliania huxleyi Proteome to Ocean Acidification
Ocean acidification due to rising atmospheric CO 2 is expected to affect the physiology of
important calcifying marine organisms, but the nature and magnitude of change is yet to be …
important calcifying marine organisms, but the nature and magnitude of change is yet to be …