Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.
…, MK Shigenaga, JW Park, P Degan… - Proceedings of the …, 1990 - National Acad Sciences
Oxidative damage to DNA is shown to be extensive and could be a major cause of the
physiological changes associated with aging and the degenerative diseases related to aging …
physiological changes associated with aging and the degenerative diseases related to aging …
Glycolytic enzymes can modulate cellular life span
H Kondoh, ME Lleonart, J Gil, J Wang, P Degan… - Cancer research, 2005 - AACR
An unbiased screen for genes that can immortalize mouse embryonic fibroblasts identified
the glycolytic enzyme phosphoglycerate mutase (PGM). A 2-fold increase in PGM activity …
the glycolytic enzyme phosphoglycerate mutase (PGM). A 2-fold increase in PGM activity …
Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column.
EM Park, MK Shigenaga, P Degan… - Proceedings of the …, 1992 - National Acad Sciences
An immunoaffinity column is described that facilitates the analysis of oxidative damage
products of DNA and RNA in urine, blood plasma, and medium isolated from cultures of …
products of DNA and RNA in urine, blood plasma, and medium isolated from cultures of …
New functions of XPC in the protection of human skin cells from oxidative damage
…, E Parlanti, M Teson, BMB de Jesus, P Degan… - The EMBO …, 2006 - embopress.org
Xeroderma pigmentosum (XP) C is involved in the recognition of a variety of bulky DNA‐distorting
lesions in nucleotide excision repair. Here, we show that XPC plays an unexpected …
lesions in nucleotide excision repair. Here, we show that XPC plays an unexpected …
[PDF][PDF] The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool
C Colussi, E Parlanti, P Degan, G Aquilina, D Barnes… - Current biology, 2002 - cell.com
Mismatch repair (MMR) corrects replication errors. It requires the MSH2, MSH6, MLH1, and
PMS2 proteins which comprise the MutSα and MutLα heterodimers [1]. Inactivation of MSH2 …
PMS2 proteins which comprise the MutSα and MutLα heterodimers [1]. Inactivation of MSH2 …
Genotoxic activity of glyphosate and its technical formulation Roundup
C Bolognesi, S Bonatti, P Degan… - Journal of Agricultural …, 1997 - ACS Publications
Glyphosate (N-phosphonomethylglycine) is an effective herbicide acting on the synthesis of
aromatic amino acids in plants. The genotoxic potential of this herbicide has been studied: …
aromatic amino acids in plants. The genotoxic potential of this herbicide has been studied: …
DNA adducts and chronic degenerative diseases. Pathogenetic relevance and implications in preventive medicine
…, J Nair, R Balansky, F van Schooten, P Degan… - … Research/Reviews in …, 1996 - Elsevier
Chronic degenerative diseases are the leading causes of death in developed countries.
Their control is exceedingly difficult due to their multiplicity and diversity, the interconnection …
Their control is exceedingly difficult due to their multiplicity and diversity, the interconnection …
[HTML][HTML] KRIT1 regulates the homeostasis of intracellular reactive oxygen species
L Goitre, F Balzac, S Degani, P Degan, S Marchi… - PloS one, 2010 - journals.plos.org
KRIT1 is a gene responsible for Cerebral Cavernous Malformations (CCM), a major
cerebrovascular disease characterized by abnormally enlarged and leaky capillaries that …
cerebrovascular disease characterized by abnormally enlarged and leaky capillaries that …
The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells
…, MF Blasi, F Chiera, P Fortini, P Degan… - … and cellular biology, 2004 - Taylor & Francis
Oxidation is a common form of DNA damage to which purines are particularly susceptible.
We previously reported that oxidized dGTP is potentially an important source of DNA 8-…
We previously reported that oxidized dGTP is potentially an important source of DNA 8-…
Accumulation of the Oxidative Base Lesion 8-Hydroxyguanine in DNA of Tumor-Prone Mice Defective in Both the Myh and Ogg1 DNA Glycosylases
MT Russo, G De Luca, P Degan, E Parlanti, E Dogliotti… - Cancer research, 2004 - AACR
The OGG1 and MYH DNA glycosylases prevent the accumulation of DNA 8-hydroxyguanine.
In Myh −/− mice, there was no time-dependent accumulation of DNA 8-hydroxyguanine in …
In Myh −/− mice, there was no time-dependent accumulation of DNA 8-hydroxyguanine in …