ASTHMA now affects one child in seven in the United Kingdom 1 . Most cases (95%) of
childhood asthma are associated with atopy, the immunoglobulin E (IgE)-mediated familial …

Background. Airway responsiveness to inhaled nonspecific bronchoconstrictive agents has
been demonstrated in normal, healthy infants. However, it is unknown whether airway …

A new and potentially more pathogenic group of human rhinovirus (HRV), group C (HRVC),
has recently been discovered. We hypothesised that HRVC would be present in children …

Atopy is a common familial state underlying allergic asthma and rhinitis. Lately, we have
assigned a gene for atopy to chromosome 11 q by linkage to the marker D11 S97. Since …

Background Maximal lung function in early adulthood is an important determinant of mortality
and COPD. We investigated whether distinct trajectories of lung function are present during …

The relationship between reduced pulmonary function in early life and persistent wheeze (PW)
in school-aged children remains uncertain. In this study, V̇maxFRC was assessed at 1 …

Background: Although IgE antibody is clearly involved in allergic reactions to environmental
allergens, this immunoglobulin is an important component of host-protective immune …

Nebulized aerosols are commonly used to deliver drugs for the treatment of respiratory disease
in children, but there are inadequate data on the dose of drug depositing in the lungs in …

Rationale: Human rhinovirus species C (HRV-C) is the most common cause of acute
wheezing exacerbations in young children presenting to hospital, but its impact on subsequent …

Ionic detergents reduce electrostatic charge on plastic spacers, thereby improving in vitro
drug delivery. The aim of this study was to gain practical information on the use of detergents …