[PDF][PDF] Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation

…, C Drouet, S Meri, TP Arstila, PT Pekkarinen… - Immunity, 2013 - cell.com
Complement is viewed as a critical serum-operative component of innate immunity, with
processing of its key component, C3, into activation fragments C3a and C3b confined to the …

[PDF][PDF] Systems-level immunomonitoring from acute to recovery phase of severe COVID-19

L Rodriguez, PT Pekkarinen, T Lakshmikanth, Z Tan… - Cell Reports …, 2020 - cell.com
Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the
lung, often with a sudden onset after 5–7 days of stable disease. Efforts to modulate this …

[HTML][HTML] Characterization of low-density granulocytes in COVID-19

LE Cabrera, PT Pekkarinen, M Alander… - PLoS …, 2021 - journals.plos.org
Severe COVID-19 is characterized by extensive pulmonary complications, to which host
immune responses are believed to play a role. As the major arm of innate immunity, neutrophils …

Inflammatory response after out‐of‐hospital cardiac arrest—Impact on outcome and organ failure development

…, MB Skrifvars, PT Pekkarinen - Acta Anaesthesiologica …, 2023 - Wiley Online Library
… In a study by Pekkarinen et al., PCT on day four (but not at ear- … Pekkarinen PT.
Inflammatory response after out-of-hospital cardiac arrest—Impact on outcome and organ failure …

Association of sequential organ failure assessment (SOFA) components with mortality

A Pölkki, PT Pekkarinen, J Takala… - Acta …, 2022 - Wiley Online Library
Background Sequential Organ Failure Assessment (SOFA) is a practical method to describe
and quantify the presence and severity of organ system dysfunctions and failures. Some …

Outcomes and healthcare-associated costs one year after intensive care-treated cardiac arrest

…, D Folger, R Raj, M Reinikainen, PT Pekkarinen… - Resuscitation, 2018 - Elsevier
Background Despite the significant socioeconomic burden associated with cardiac arrest (CA),
data on CA patients’ long-term outcome and healthcare-associated costs are limited. The …

Early hyperoxemia is not associated with cardiac arrest outcome

…, E Litonius, I Efendijev, D Folger, R Raj, PT Pekkarinen… - Resuscitation, 2019 - Elsevier
Aim Studies suggest that hyperoxemia increases short-term mortality after cardiopulmonary
resuscitation (CPR), but the effect of hyperoxemia on long-term outcomes is unclear. We …

Vasoactive Inotropic Score compared to the sequential organ failure assessment cardiovascular score in intensive care

A Pölkki, PT Pekkarinen, P Lahtinen… - Acta …, 2023 - Wiley Online Library
PekkarinenPekkarinen … Dr Pekkarinen was supported by grants from Finska
Läkaresällskapet and Einar och Karin Stroems stiftelse. The authors declare no conflicts of interest. …

A disparity in the association of asthma, rhinitis, and eczema with allergen‐specific IgE between Finnish and Russian Karelia

PT Pekkarinen, L Von Hertzen, T Laatikainen… - Allergy, 2007 - Wiley Online Library
Background: A substantial variation in the association of asthma, rhinitis and eczema with
elevated serum allergen‐specific immunoglobulin E (sIgE) levels between different …

The FOXP3+ subset of human CD4+CD8+ thymocytes is immature and subject to intrathymic selection

H Tuovinen, PT Pekkarinen, LH Rossi… - Immunology and cell …, 2008 - Wiley Online Library
FOXP3, believed to be the regulatory T (Treg)‐cell determining factor, is already expressed
at the CD4 + CD8 + thymocyte stage, but there is disagreement whether these cells are the …