Background Inhaled hypertonic saline acutely increases mucociliary clearance and, in short-term
trials, improves lung function in people with cystic fibrosis. We tested the safety and …

Hypertonic saline is a strong sterile solution of salt water that can be inhaled as a nebulized
medication for people with cystic fibrosis (CF). To examine how it should be applied clinically…

… Elkins, Mark R a,b,c ; Bye, Peter TP a,b,c … Correspondence to Peter TP Bye MBBS, FRACP,
PhD, Department of Respiratory Medicine, Royal Prince Alfred Hospital, Missenden Road …

Severe nocturnal hypoxemia may occur in patients with respiratory muscle weakness caused
by neuromuscular disorders. Negative pressure ventilators may be partially effective in …

Although its effects on some outcomes are unclear, the overall effect of exercise on quality
of life is substantially beneficial and the evidence available for other specific outcomes is …

We investigated the effect on daytime respiratory function and quality of sleep, of providing
adequate ventilation either by intermittent positive pressure ventilation (EPPV) or by …

Background The airways in patients with cystic fibrosis (CF) are characterized by the accumulation
of tenacious, dehydrated mucus that is a precursor for chronic infection, inflammation, …

Background The physiologic mechanisms by which exercise may clear secretions in subjects
with cystic fibrosis (CF) are unknown. The purpose of this study was to compare ventilation, …

The pattern of change in arterial oxyhemoglobin saturation (Sa O 2 %) during sleep was
characterized in 13 patients with interstitial lung disease (ILD), 12 off whom had restrictive …

OBJECTIVE: Determine the SenseWear Pro3 Armband (SWA) accuracy for estimating energy
expenditure (EE) and step count during treadmill walking in cystic fibrosis (CF) compared …