User profiles for P. Okerholm

Pamela Okerholm

Association for Veterinary Informatics
Verified email at avinformatics.org
Cited by 5

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A (4) in N-dealkylation and C-hydroxylation.

CH Yun, RA Okerholm, FP Guengerich - Drug metabolism and Disposition, 1993 - ASPET
… but antibodies recognizing other P-450s had no … P-450 3A4 and by partially purified yeast
recombinant P-450 3A4. These results provide evidence that P-450 3A4 (and possibly other P-…

Inhaled calcium salts inhibit tobacco smoke-induced inflammation by modulating expression of chemokines and cytokines

…, E Berry, T Brogan, S Kong, P Okerholm… - Pulmonary …, 2018 - Elsevier
… exposure for 5 days (p < 0.01 by unpaired Students t-test of each cell type; data not shown).
… Data were analyzed by one-way ANOVA and Tukey's post-test (*p < 0.05, and ***p < 0.005 …

Inhaled calcium salts reduce acute airway inflammation associated with tobacco smoke exposure

…, D Spicer, J Kenyon, P Okerholm, P Wright… - … STUDIES IN ASTHMA …, 2011 - atsjournals.org
… Notably, the effect of PUR113 was comparable to the p38 MAPK p inhibitor. In a second
experiment, we compared the QD vs. BID efficacy of PUR113; QD dosing was performed 1h …

Reduced neutrophilic airway inflammation by inhalation of dry powder calcium salts in a mouse model of sub-chronic tobacco smoke exposure

…, P Woodman, D Spicer, P Okerholm… - … OF COPD: OLD AND …, 2012 - atsjournals.org
RATIONALE: Inhaled dry powder (DP) calcium (Ca) salts exhibit anti-infective and anti-inflammatory
efficacy in preclinical models. This multi-factorial mechanism that provides a novel …

Acute hemodynamic effect of oral MDL 17,043 in severe congestive heart failure

…, RB Spangenberg, JF Lang, RA Okerholm - The American journal of …, 1984 - Elsevier
… (from 8.0 f 1.4 to 5.8 f 1.2 vol%, p <O.OI), heart rate increased by 8% (from 85 f I8 to 92 f I8
beatslmin, p <0.05), stroke volume index increased by 22% (from 23 f 5 to 28 f 4 ml/beat/m2, p

The influence of gender and food on the pharmacokinetics of sodium oxybate oral solution in healthy subjects

LA Borgen, R Okerholm, D Morrison… - The Journal of Clinical …, 2003 - Wiley Online Library
… the fed condition as compared to the fasted state (p < 0.05). Mean AUC 0-∞ values were
likewise significantly higher in the fasted versus fed state (p < 0.05). The median t max of 2.00 …

Torsades de pointes occurring in association with terfenadine use

DR Mathews, B McNutt, R Okerholm, M Flicker… - Jama, 1991 - jamanetwork.com
… To the Editor.\p=m-\Monahanet al1 reported a case of torsades de pointes after concomitant
… Since ketoconazole inhibits cytochrome P-450, we studied the potential for other known …

[PDF][PDF] ALTERNATIVE STRATEGIES FOR DISEASE SURVEILLANCE IN THE VETERINARY MEDICAL COMMUNITY

PA Okerholm - 2016 - researchgate.net
The 2012-2013 faculty of the Tufts Conservation Medicine program inspired this case study.
I would like to especially thank Dr. Alison Robbins, Dr. Peter Rabinowitz, and Dr. Julie Ellis …

The pharmacokinetics of sodium oxybate oral solution following acute and chronic administration to narcoleptic patients

LA Borgen, RA Okerholm, A Lai… - The Journal of Clinical …, 2004 - Wiley Online Library
This trial was conducted to evaluate the pharmacokinetics and safety of a sodium oxybate (gamma‐hydroxybutyrate
[GHB]) oral solution in narcoleptic patients after acute and chronic …

Comparison of the pharmacokinetics of two nicotine transdermal systems: nicoderm and habitrol

SK Gupta, RA Okerholm, M Eller, G Wei… - The Journal of …, 1995 - Wiley Online Library
… The mean nicotine t max value for the Nicoderm system was significantly shorter (P < .001)
than that for Habitrol (2.7 versus 8.6 hours). Steady state cotinine AUC values and plasma …