User profiles for P. Hiemstra

Paul Hiemstra

Windesheim University of Applied Sciences
Verified email at windesheim.nl
Cited by 988

Innate immunity in the lung: how epithelial cells fight against respiratory pathogens

R Bals, PS Hiemstra - European Respiratory Journal, 2004 - Eur Respiratory Soc
The human lung is exposed to a large number of airborne pathogens as a result of the daily
inhalation of 10,000 litres of air. The observation that respiratory infections are nevertheless …

The innate immune function of airway epithelial cells in inflammatory lung disease

PS Hiemstra, PB McCray, R Bals - European respiratory …, 2015 - Eur Respiratory Soc
The airway epithelium is now considered to be central to the orchestration of pulmonary
inflammatory and immune responses, and is also key to tissue remodelling. It acts as the first …

An emerging class of air pollutants: potential effects of microplastics to respiratory human health?

…, LA de Weger, PS Hiemstra… - Science of the total …, 2020 - Elsevier
It is increasingly recognized that the ubiquity of convenient single-use plastic has resulted in
a global plastic pollution challenge, with substantial environmental and health …

[HTML][HTML] An angiogenic role for the human peptide antibiotic LL-37/hCAP-18

…, P Boekstegers, U Welsch, PS Hiemstra… - The Journal of …, 2003 - Am Soc Clin Investig
… Results were considered statistically significant for P values … P < 0.05 as compared with the
solvent group (n = 6/group; three … P < 0.05 as compared with the buffer control (n = 4/group). …

Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3

…, J Calafat, GS Tjabringa, PS Hiemstra… - Blood, The Journal …, 2001 - ashpublications.org
Cathelicidins are a family of antimicrobial proteins found in the peroxidase-negative granules
of neutrophils. The known biologic functions reside in the C-terminus, which must be …

4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease

…, AJL Crowther, PS Hiemstra… - American journal of …, 2002 - atsjournals.org
… and FEV 1 (p < 0.05) and a positive correlation between 4-HNE adducts and TGF-β 1
protein and mRNA as well as γ-GCS mRNA levels in airway and alveolar epithelium (p < 0.01). …

In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-γ and TNF-α mediated up-regulation during inflammation

…, B de Vries, MARC Daemen, PS Hiemstra… - The Journal of …, 2002 - journals.aai.org
The reported requirement of functional Toll-like receptor (TLR) 4 for resistance to Gram-negative
pyelonephritis prompted us to localize the expression of TLR2 and TLR4 mRNA in the …

[HTML][HTML] Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

…, PLSM Gordts, JD Esko, PS Hiemstra… - Nature …, 2015 - nature.com
Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma
triglyceride levels and reducing obesity. However, the precise role of BAT in plasma …

The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor

…, N Borregaard, KF Rabe, PS Hiemstra - The Journal of …, 2003 - journals.aai.org
Antimicrobial peptides produced by epithelial cells and neutrophils represent essential
elements of innate immunity, and include the defensin and cathelicidin family of antimicrobial …

Real-time automatic interpolation of ambient gamma dose rates from the Dutch radioactivity monitoring network

PH Hiemstra, EJ Pebesma, CJW Twenhöfel… - Computers & …, 2009 - Elsevier
Detection of radiological accidents and monitoring the spread of the contamination is of great
importance. Following the Chernobyl accident many European countries have installed …