Serum periostin as a biomarker for comorbid chronic rhinosinusitis in patients with asthma

…, M Yokota, K Fukumitsu, N Takeda… - Annals of the …, 2017 - atsjournals.org
Rationale: Periostin is a matricellular protein that is involved in the pathophysiology of allergic
rhinitis, chronic rhinosinusitis, and asthma. Associations of serum periostin with systemic …

Tiotropium attenuates refractory cough and capsaicin cough reflex sensitivity in patients with asthma

K Fukumitsu, Y Kanemitsu, T Asano, N Takeda… - The Journal of Allergy …, 2018 - Elsevier
Background Asthmatic cough is often refractory to standard treatments such as inhaled
corticosteroids (ICS) and long-acting β 2 agonists (LABA). Tiotropium may modulate cough reflex …

Increased capsaicin sensitivity in patients with severe asthma is associated with worse clinical outcome

…, K Fukumitsu, R Kurokawa, N Takeda… - American Journal of …, 2020 - atsjournals.org
Rationale: Capsaicin cough reflex sensitivity (C-CS) is associated with poorly controlled
asthma, although its association with severe asthma remains unknown. Objectives: To …

Clinical impact of gastroesophageal reflux disease in patients with subacute/chronic cough

Y Kanemitsu, R Kurokawa, N Takeda… - Allergology …, 2019 - jstage.jst.go.jp
Background: While gastroesophageal reflux disease (GERD) is one of the commonest causes
of subacute/chronic cough along with cough-variant asthma (CVA) and rhinosinusitis, its …

Effect of anti-reflux treatment on gastroesophageal reflux-associated chronic cough: Implications of neurogenic and neutrophilic inflammation

N Takeda, M Takemura, Y Kanemitsu, H Hijikata… - Journal of …, 2020 - Taylor & Francis
Objective: Gastroesophageal reflux disease (GERD) is an important cause of chronic cough.
Substance P (SP) has been implicated in the pathophysiology of cough. Proton pump …

[HTML][HTML] Serum creatinine/cystatin C ratio is a surrogate marker for sarcopenia in patients with idiopathic pulmonary fibrosis

K Fujita, H Ohkubo, A Nakano, N Takeda… - BMC pulmonary …, 2022 - Springer
Background The serum creatinine/cystatin C (Cr/CysC) ratio has attracted attention as a
marker for sarcopenia, but has not been studied in patients with idiopathic pulmonary fibrosis (…

An inflammatory stimulus sensitizes TRPA1 channel to increase cytokine release in human lung fibroblasts

JMG Yap, T Ueda, N Takeda, K Fukumitsu, S Fukuda… - Cytokine, 2020 - Elsevier
External stimuli such as cigarette smoke and house dust mite are often involved in the
development and exacerbation of asthma. These risk factors could activate or sensitize transient …

[HTML][HTML] Circulating Th17. 1 cells as candidate for the prediction of therapeutic response to abatacept in patients with rheumatoid arthritis: an exploratory research

S Maeda, S Osaga, T Maeda, N Takeda, S Tamechika… - PLoS …, 2019 - journals.plos.org
T-helper (Th)17.1 cells exhibit high pathogenicity in inflammatory diseases. This study
aimed to identify the changes in the proportions of Th subsets, including Th17.1, which are …

Interfering with airway nerves in cough associated with asthma

A Niimi, K Fukumitsu, N Takeda, Y Kanemitsu - Pulmonary Pharmacology & …, 2019 - Elsevier
Cough is a troublesome and often refractory symptom of asthma, which is associated with
poor control of disease. The pathogenesis of asthmatic cough has mainly been attributed to …

[HTML][HTML] Optimal cut-off value and clinical usefulness of the Adherence Starts with Knowledge-12 in patients with asthma taking inhaled corticosteroids

…, M Nishio, K Fukumitsu, N Takeda… - Journal of thoracic …, 2017 - ncbi.nlm.nih.gov
Background Non-adherence to inhalation regimens is common in asthmatic patients. The
Adherence Starts with Knowledge-12 (ASK-12) survey was developed to detect and address …