User profiles for Nilesh J. Samani

Nilesh Samani

Professor of Cardiology, University of Leicester
Verified email at le.ac.uk
Cited by 217870

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

, … Trust Case Control Consortium. Samani Nilesh J 11 … - Nature …, 2009 - nature.com
We conducted a genome-wide association study testing single nucleotide polymorphisms (SNPs)
and copy number variants (CNVs) for association with early-onset myocardial …

[HTML][HTML] Genomewide association analysis of coronary artery disease

NJ Samani, J Erdmann, AS Hall… - … England Journal of …, 2007 - Mass Medical Soc
Background Modern genotyping platforms permit a systematic search for inherited components
of complex diseases. We performed a joint analysis of two genomewide association …

[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

…, H Hólm, EL Ding, T Johnson, H Schunkert, NJ Samani… - The Lancet, 2012 - thelancet.com
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Common variants near MC4R are associated with fat mass, weight and risk of obesity

…, WH Ouwehand, MJ Caulfield, NJ Samani… - Nature …, 2008 - nature.com
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …

Genome-wide association study identifies eight loci associated with blood pressure

…, A Dominiczak, SJ Newhouse, NJ Samani, J Webster… - Nature …, 2009 - nature.com
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

…, H Jonsdottir, U Thorsteinsdottir, NJ Samani… - Nature …, 2004 - nature.com
We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12–13.
A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning …

Human metabolic individuality in biomedical and pharmaceutical research

…, J Raffler, JS Ried, W Römisch-Margl, NJ Samani… - Nature, 2011 - nature.com
Genome-wide association studies (GWAS) have identified many risk loci for complex diseases,
but effect sizes are typically small and information on the underlying biological processes …

Identification of seven loci affecting mean telomere length and their association with disease

…, TD Spector, P van der Harst, NJ Samani - Nature …, 2013 - nature.com
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Genome-wide association analysis identifies 20 loci that influence adult height

…, JRB Perry, S Stevens, AS Hall, NJ Samani… - Nature …, 2008 - nature.com
Adult height is a model polygenic trait, but there has been limited success in identifying the
genes underlying its normal variation. To identify genetic variants influencing adult human …

Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study

…, I Ford, J Shepherd, CJ Packard, NJ Samani - The Lancet, 2007 - thelancet.com
Background Inter-individual differences in biological ageing could affect susceptibility to
coronary heart disease. Our aim was to determine whether mean leucocyte telomere length is a …