Increasing evidence indicates that chronic inflammatory and immune responses play key roles
in the development and progression of COPD. Recent data provide evidence for a role in …

Advances in the management of malignancies and organ failures have led to substantial
increases in survival as well as in the number of cancer patients requiring intensive care unit (…

RESULTS There is strong evidence of the effects of maternal tobacco use and secondhand
smoke exposure on adverse pregnancy outcomes. Tobacco use is the leading preventable …

Proper management of COVID-19 mandates better understanding of disease pathogenesis.
The sudden clinical deterioration 7–8 days after initial symptom onset suggests that severe …

A central paradigm of immunity is that interferon (IFN)-mediated antiviral responses precede
pro-inflammatory ones, optimizing host protection and minimizing collateral damage 1 , 2 . …

Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of
COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild …

As of April 1, 2020, 885,689 cases of infections by the novel coronavirus SARS-CoV-2 (COVID-19)
have been recorded worldwide; 44,217 of them have died (https://www. worldometers…

Background A subanalysis of a randomized clinical trial indicated sepsis survival benefit
from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like …

BACKGROUND: It has been shown that interleukin (IL)-18 levels in induced sputum are
reduced in asthmatic and healthy smokers. However, in chronic obstructive pulmonary disease (…

Asthma is the commonest respiratory disease and one of unceasingly increasing prevalence
and burden. As such, asthma has attracted a major share or scientific interest and clinical …