Innate immune modulation in chronic obstructive pulmonary disease: moving closer toward vitamin D therapy
N Heulens, H Korf, W Janssens - Journal of Pharmacology and Experimental …, 2015 - ASPET
Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory
diseases and a major cause of morbidity and mortality worldwide. Disturbed innate immune …
diseases and a major cause of morbidity and mortality worldwide. Disturbed innate immune …
[HTML][HTML] Vitamin D deficiency exacerbates COPD-like characteristics in the lungs of cigarette smoke-exposed mice
N Heulens, H Korf, N Cielen, E De Smidt, K Maes… - Respiratory …, 2015 - Springer
Background Chronic obstructive pulmonary disease (COPD) is characterized by excessive
inflammation and disturbed bacterial clearance in the airways. Although cigarette smoke (CS) …
inflammation and disturbed bacterial clearance in the airways. Although cigarette smoke (CS) …
[HTML][HTML] 1, 25-Dihydroxyvitamin D modulates antibacterial and inflammatory response in human cigarette smoke-exposed macrophages
N Heulens, H Korf, C Mathyssen, S Everaerts… - PloS one, 2016 - journals.plos.org
Cigarette smoking is associated with increased inflammation and defective antibacterial
responses in the airways. Interestingly, vitamin D has been shown to suppress inflammation and …
responses in the airways. Interestingly, vitamin D has been shown to suppress inflammation and …
Antielastin B-cell and T-cell immunity in patients with chronic obstructive pulmonary disease
M Rinaldi, A Lehouck, N Heulens, R Lavend'Homme… - Thorax, 2012 - thorax.bmj.com
Rationale Antielastin autoimmunity has been hypothesised to drive disease progression in
chronic obstructive pulmonary disease (COPD). The proposed mechanism is currently …
chronic obstructive pulmonary disease (COPD). The proposed mechanism is currently …
DNA methylation profiling of non-small cell lung cancer reveals a COPD-driven immune-related signature
…, J Vansteenkiste, H Decaluwé, N Heulens… - Thorax, 2015 - thorax.bmj.com
Introduction Non-small cell lung cancer (NSCLC) is a heterogeneous disorder consisting of
distinct molecular subtypes each characterised by specific genetic and epigenetic profiles. …
distinct molecular subtypes each characterised by specific genetic and epigenetic profiles. …
Interaction between physical activity and smoking on lung, muscle, and bone in mice
N Cielen, K Maes, N Heulens, T Troosters… - American journal of …, 2016 - atsjournals.org
Physical inactivity is an important contributor to skeletal muscle weakness, osteoporosis,
and weight loss in chronic obstructive pulmonary disease. However, the effects of physical …
and weight loss in chronic obstructive pulmonary disease. However, the effects of physical …
[HTML][HTML] Vitamin D deficiency impairs skeletal muscle function in a smoking mouse model
N Cielen, N Heulens, K Maes… - Journal of …, 2016 - joe.bioscientifica.com
Chronic obstructive pulmonary disease (COPD) is associated with skeletal muscle
dysfunction. Vitamin D plays an important role in muscle strength and performance in healthy …
dysfunction. Vitamin D plays an important role in muscle strength and performance in healthy …
Airway infection with Nontypeable Haemophilus influenzae is more rapidly eradicated in vitamin D deficient mice
…, TT Ajime, H Korf, K Maes, N Heulens… - The Journal of steroid …, 2019 - Elsevier
Chronic obstructive pulmonary disease (COPD), which is characterized by an excessive
inflammatory response of the airways, is often complicated by exacerbations. Vitamin D …
inflammatory response of the airways, is often complicated by exacerbations. Vitamin D …
Severe vitamin D deficiency: a biomarker of exacerbation risk?
N Heulens, M Decramer, W Janssens - American journal of …, 2013 - atsjournals.org
We greatly appreciate the call for cautious interpretation of the Anticoagulation Effectiveness
(ACE) results by Dr. Tzouvelekis and colleagues. As we highlighted in the DISCUSSION …
(ACE) results by Dr. Tzouvelekis and colleagues. As we highlighted in the DISCUSSION …
The effects of smoking on whisker movements: a quantitative measure of exploratory behaviour in rodents
RA Grant, N Cielen, K Maes, N Heulens, GLJ Galli… - Behavioural …, 2016 - Elsevier
Nicotine, an important component of cigarette smoke, is a neurotransmitter that contributes
to stress, depression and anxiety in smokers. In rodents, it increases anxiety and reduces …
to stress, depression and anxiety in smokers. In rodents, it increases anxiety and reduces …