The transient receptor potential subfamily A member 1 (TRPA1) is a non-selective cation
channel implicated in the pathogenesis of several airway diseases like asthma and chronic …

The capsaicin receptor TRPV1 (transient receptor potential cation channel, subfamily V,
member 1) is a polymodal nociceptor whose expression is upregulated in several painful …

Cough is a protective reflex action that helps clear the respiratory tract which is continuously
exposed to airborne environmental irritants. However, chronic cough presents itself as a …

Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel is expressed abundantly on the
C fibers that innervate almost entire respiratory tract starting from oral cavity and oropharynx…

The synthesis and structure-activity relationship studies of a series of compounds from
imidazopyridazinone scaffold as PDE7 inhibitors are disclosed. Potent analogs such as …

A novel series of N-aryl-3,4-dihydro-1′H-spiro[chromene-2,4′-piperidine]-1′-carboxamides
was identified as transient receptor potential melastatin 8 (TRPM8) channel blockers …

The design, synthesis and structure activity relationship studies of a series of compounds
from benzo[d]imidazo[5,1-b]thiazole scaffold as phosphodiesterase 10A (PDE10A) inhibitors …

Human beings have evolved with a powerful peripheral thermo-sensory capacity to maintain
thermal homeostasis and to avoid potentially harmful stimuli. Specialized sensory neurons …

We report the design and synthesis of novel 5,6-diarylated pyridin-2(1H)-one derivatives as
pharmacophoric PDE10A inhibitors. This highly potent molecular scaffold was developed …

The discovery and SAR of potent, selective dioxane-fused tricyclic benz[d]imidazole derivatives
as mPGES-1 inhibitor are herein described. Various amide modifications in this series …