[HTML][HTML] Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation
ME Monzon, N Fregien, N Schmid, NS Falcon… - Journal of Biological …, 2010 - ASBMB
Hyaluronidase 2 (Hyal2) is a hyaluronan (HA)-degrading enzyme found intracellularly or/and
anchored to the plasma membrane through glycosylphosphatidylinositol (GPI). Normal …
anchored to the plasma membrane through glycosylphosphatidylinositol (GPI). Normal …
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP
A Schmid, Z Sutto, MC Nlend, G Horvath… - The Journal of general …, 2007 - rupress.org
Ciliated airway epithelial cells are subject to sustained changes in intracellular CO 2 /HCO 3
− during exacerbations of airway diseases, but the role of CO 2 /HCO 3 − -sensitive soluble …
− during exacerbations of airway diseases, but the role of CO 2 /HCO 3 − -sensitive soluble …
Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway
…, N Schmid, MA Fragoso, A Schmid… - American journal of …, 2007 - atsjournals.org
Most inhaled β 2 -adrenergic agonist and anticholinergic bronchodilators have low lipid
solubility because of their transient or permanent positive net charge at physiologic pH. Airway …
solubility because of their transient or permanent positive net charge at physiologic pH. Airway …
Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells
A Schmid, G Bai, N Schmid, M Zaccolo… - Journal of cell …, 2006 - journals.biologists.com
Airway ciliary beat frequency regulation is complex but in part influenced by cyclic adenosine
monophosphate (cAMP)-mediated changes in cAMP-dependent kinase activity, yet the …
monophosphate (cAMP)-mediated changes in cAMP-dependent kinase activity, yet the …
Location of spermine and other polyamines on DNA as revealed by photoaffinity cleavage with poly (amino) benzenediazonium salts
N Schmid, JP Behr - Biochemistry, 1991 - ACS Publications
Materials and Methods The p-diazonioanilides of L-ornithine (PuN23+) and 5-carboxy-L-spermine
(SperN25+) were prepared as previously described (Behr, 1989). The plasmid …
(SperN25+) were prepared as previously described (Behr, 1989). The plasmid …
Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells
ME Monzón, D Manzanares, N Schmid… - American journal of …, 2008 - atsjournals.org
Hyaluronan (HA) is present at the apical surface of airway epithelium as a high-molecular-weight
polymer. Since HA depolymerization initiates a cascade of events that results in kinin …
polymer. Since HA depolymerization initiates a cascade of events that results in kinin …
[HTML][HTML] Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation
A Schmid, Z Sutto, N Schmid, L Novak, P Ivonnet… - Journal of biological …, 2010 - ASBMB
Human airway cilia contain soluble adenylyl cyclase (sAC) that produces cAMP upon HCO
3 − /CO 2 stimulation to increase ciliary beat frequency (CBF). Because apical HCO 3 − …
3 − /CO 2 stimulation to increase ciliary beat frequency (CBF). Because apical HCO 3 − …
The effect of corticosteroids on the disposal of long-acting β2-agonists by airway smooth muscle cells
G Horvath, ES Mendes, N Schmid, A Schmid… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Organic cation transporters (OCTs) have an important role in tissue distribution
and elimination of cationic drugs. Carrier-mediated disposal of cationic bronchodilators …
and elimination of cationic drugs. Carrier-mediated disposal of cationic bronchodilators …
Recognition of DNA sequences by strand replacement with polyamino-oligonucleotides
N Schmid, JP Behr - Tetrahedron letters, 1995 - Elsevier
A modified 11-mer oligodeoxyribonucleotide1 * of sequence ATTG * AATG * TTT, containing
two spermine residues linked to the C2 position of inosine (G * ; 2-aminoinosine is …
two spermine residues linked to the C2 position of inosine (G * ; 2-aminoinosine is …
[HTML][HTML] Direct identification of a polyamine binding domain on the regulatory subunit of the protein kinase casein kinase 2 by photoaffinity labeling
Phosphorylation of many protein substrates by the protein kinase casein kinase 2 (CK2) is
stimulated severalfold in the presence of polyamines such as spermine. Previous experiments …
stimulated severalfold in the presence of polyamines such as spermine. Previous experiments …