Biological, clinical and population relevance of 95 loci for blood lipids

…, I Pichler, M Perola, BWJH Penninx, NL Pedersen… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease

…, JB Nielsen, LG Fritsche, LF Thomas, LM Pedersen… - Nature …, 2021 - nature.com
Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

…, L Lind, G Dedoussis, I Njølstad, NL Pedersen… - Nature …, 2012 - nature.com
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D),
we conducted a meta-analysis of genetic variants on the Metabochip, including …

Role of genes and environments for explaining Alzheimer disease

…, S Berg, A Fiske, NL Pedersen - Archives of general …, 2006 - jamanetwork.com
Context Twin studies using selected samples have shown high heritability for Alzheimer
disease (AD). Objective To evaluate genetic and environmental influences on AD in a fully …

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk

…, LK Davis, H Stefansson, K Stefansson, NL Pedersen… - Nature …, 2019 - nature.com
Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …

Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)

…, NL Pedersen, CG Östenson, L Fratiglioni… - The lancet …, 2013 - thelancet.com
Background Ambient air pollution is suspected to cause lung cancer. We aimed to assess
the association between long-term exposure to ambient air pollution and lung cancer …

Large-scale association analysis identifies new risk loci for coronary artery disease

…, WH Ouwehand, S Parish, JE Park, NL Pedersen… - Nature …, 2013 - nature.com
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

[HTML][HTML] The body-mass index of twins who have been reared apart

AJ Stunkard, JR Harris, NL Pedersen… - New England journal …, 1990 - Mass Medical Soc
To assess the relative importance of genetic and environmental effects on the body-mass
index (weight in kilograms divided by the square of the height in meters), we studied samples …

Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project

…, U De Faire, NL Pedersen, CG Östenson, L Fratiglioni… - The lancet, 2014 - thelancet.com
Background Few studies on long-term exposure to air pollution and mortality have been
reported from Europe. Within the multicentre European Study of Cohorts for Air Pollution Effects (…

Genome-wide association study identifies 74 loci associated with educational attainment

…, WER Ollier, A Palotie, L Paternoster, NL Pedersen… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …