Biological, clinical and population relevance of 95 loci for blood lipids
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
…, JB Nielsen, LG Fritsche, LF Thomas, LM Pedersen… - Nature …, 2021 - nature.com
Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
…, L Lind, G Dedoussis, I Njølstad, NL Pedersen… - Nature …, 2012 - nature.com
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D),
we conducted a meta-analysis of genetic variants on the Metabochip, including …
we conducted a meta-analysis of genetic variants on the Metabochip, including …
Role of genes and environments for explaining Alzheimer disease
…, S Berg, A Fiske, NL Pedersen - Archives of general …, 2006 - jamanetwork.com
Context Twin studies using selected samples have shown high heritability for Alzheimer
disease (AD). Objective To evaluate genetic and environmental influences on AD in a fully …
disease (AD). Objective To evaluate genetic and environmental influences on AD in a fully …
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
…, LK Davis, H Stefansson, K Stefansson, NL Pedersen… - Nature …, 2019 - nature.com
Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)
…, NL Pedersen, CG Östenson, L Fratiglioni… - The lancet …, 2013 - thelancet.com
Background Ambient air pollution is suspected to cause lung cancer. We aimed to assess
the association between long-term exposure to ambient air pollution and lung cancer …
the association between long-term exposure to ambient air pollution and lung cancer …
Large-scale association analysis identifies new risk loci for coronary artery disease
…, WH Ouwehand, S Parish, JE Park, NL Pedersen… - Nature …, 2013 - nature.com
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …
[HTML][HTML] The body-mass index of twins who have been reared apart
AJ Stunkard, JR Harris, NL Pedersen… - New England journal …, 1990 - Mass Medical Soc
To assess the relative importance of genetic and environmental effects on the body-mass
index (weight in kilograms divided by the square of the height in meters), we studied samples …
index (weight in kilograms divided by the square of the height in meters), we studied samples …
Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project
…, U De Faire, NL Pedersen, CG Östenson, L Fratiglioni… - The lancet, 2014 - thelancet.com
Background Few studies on long-term exposure to air pollution and mortality have been
reported from Europe. Within the multicentre European Study of Cohorts for Air Pollution Effects (…
reported from Europe. Within the multicentre European Study of Cohorts for Air Pollution Effects (…
Genome-wide association study identifies 74 loci associated with educational attainment
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …