[HTML][HTML] Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

…, I Romieu, DJ Van Den Berg, D Hu, NN Hansel… - Nature …, 2011 - ncbi.nlm.nih.gov
Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

Severe Community-Onset Pneumonia in Healthy Adults Caused by Methicillin-Resistant Staphylococcus aureus Carrying the Panton-Valentine Leukocidin Genes

…, G Sinha, T Ross, M Cai, NN Hansel… - Clinical infectious …, 2005 - academic.oup.com
Background . Recent worldwide reports of community-onset skin abscesses, outbreaks of
furunculosis, and severe pneumonia associated with methicillin-resistant Staphylococcus …

Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission

…, FME Franssen, U Frey, ML Han, NN Hansel… - The Lancet, 2022 - thelancet.com
Despite substantial progress in reducing the global impact of many non-communicable
diseases, including heart disease and cancer, morbidity and mortality due to chronic respiratory …

[HTML][HTML] Clinical significance of symptoms in smokers with preserved pulmonary function

…, JL Curtis, NA Gouskova, NN Hansel… - … England Journal of …, 2016 - Mass Medical Soc
Background Currently, the diagnosis of chronic obstructive pulmonary disease (COPD)
requires a ratio of forced expiratory volume in 1 second (FEV 1 ) to forced vital capacity (FVC) of …

Detectable clonal mosaicism from birth to old age and its relationship to cancer

…, Q Wei, L Wang, JE Lee, KC Barnes, NN Hansel… - Nature …, 2012 - nature.com
We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …

[HTML][HTML] The clinical features of the overlap between COPD and asthma

M Hardin, EK Silverman, RG Barr, NN Hansel… - Respiratory …, 2011 - Springer
Background The coexistence of COPD and asthma is widely recognized but has not been
well described. This study characterizes clinical features, spirometry, and chest CT scans of …

[HTML][HTML] Airway mucin concentration as a marker of chronic bronchitis

…, CB Cooper, MLK Han, NN Hansel… - … England Journal of …, 2017 - Mass Medical Soc
Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
bronchitic and emphysematous components. In one biophysical model, the concentration of …

[HTML][HTML] Assembly of a pan-genome from deep sequencing of 910 humans of African descent

…, A Mayorga, J Knight-Madden, T Hartert, NN Hansel… - Nature …, 2019 - nature.com
We used a deeply sequenced dataset of 910 individuals, all of African descent, to construct
a set of DNA sequences that is present in these individuals but missing from the reference …

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

…, PS Bakke, JD Crapo, TH Beaty, NN Hansel… - Nature …, 2017 - nature.com
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association discovery …

Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study

…, L Zhang, J Murphy, NN Hansel… - American journal of …, 2011 - atsjournals.org
Rationale: The characterization of young adults who develop late-onset diseases may
augment the detection of novel genes and promote new pathogenic insights. Methods: We …