User profiles for N.N. Chegou

Novel N Chegou

Research Scientist (Professor) at Stellenbosch University
Verified email at sun.ac.za
Cited by 5342

Tuberculosis: advances and challenges in development of new diagnostics and biomarkers

…, M Bates, TD McHugh, NN Chegou… - The Lancet Infectious …, 2018 - thelancet.com
Tuberculosis remains the leading cause of death from an infectious disease worldwide. Early
and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis is …

Beyond the IFN-γ horizon: biomarkers for immunodiagnosis of infection with Mycobacterium tuberculosis

NN Chegou, J Heyckendorf, G Walzl… - European …, 2014 - Eur Respiratory Soc
Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M.
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …

Tuberculosis assays: past, present and future

NN Chegou, KGP Hoek, M Kriel… - Expert review of anti …, 2011 - Taylor & Francis
Recent developments in the field of TB diagnostics, including the introduction of the Xpert
MTB/RIF assay in field testing, raise the hope for faster and more accurate identification of …

[HTML][HTML] Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report

NN Chegou, GF Black, M Kidd, PD Van Helden… - BMC pulmonary …, 2009 - Springer
Background Interferon gamma release assays, including the QuantiFERON ® TB Gold In
Tube (QFT) have been shown to be accurate in diagnosing Mycobacterium tuberculosis …

[HTML][HTML] Host blood RNA signatures predict the outcome of tuberculosis treatment

…, DE Zak, N Du Plessis, AG Loxton, NN Chegou… - Tuberculosis, 2017 - Elsevier
Biomarkers for tuberculosis treatment outcome will assist in guiding individualized treatment
and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of …

Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs …

NN Chegou, JS Sutherland, S Malherbe, AC Crampin… - Thorax, 2016 - thorax.bmj.com
Background User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently
needed at points of care in resource-limited settings. We investigated host biomarkers …

Hypercytokinaemia accompanies HIV–tuberculosis immune reconstitution inflammatory syndrome

…, K Matthews, R Seldon, NN Chegou… - European …, 2011 - Eur Respiratory Soc
Increased access to combination antiretroviral therapy in areas co-endemic for tuberculosis (TB)
and HIV-1 infection is associated with an increased incidence of immune reconstitution …

[HTML][HTML] RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

…, SC Mendelsohn, S Suliman, NN Chegou… - Scientific reports, 2020 - nature.com
Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently
needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature…

High level of discordant IGRA results in HIV-infected adults and children

…, AC Hesseling, NN Chegou… - … of Tuberculosis and …, 2008 - ingentaconnect.com
SETTING: Tygerberg district, Western Cape Province, South Africa.OBJECTIVE: To measure
the agreement of two interferon-gamma release assays (IGRAs) and the tuberculin skin test …

[HTML][HTML] Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment …

…, K Stanley, G Van Der Spuy, G Walzl, NN Chegou - Oncotarget, 2016 - ncbi.nlm.nih.gov
… , van der Spuy G, Walzl G, Chegou NN. Host biomarkers detected in saliva show promise as
… , van der Spuy GD, Walzl G, Chegou NN. Differential expression of host biomarkers in saliva …