User profiles for N.N. Chegou
Novel N ChegouResearch Scientist (Professor) at Stellenbosch University Verified email at sun.ac.za Cited by 5342 |
Tuberculosis: advances and challenges in development of new diagnostics and biomarkers
Tuberculosis remains the leading cause of death from an infectious disease worldwide. Early
and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis is …
and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis is …
Beyond the IFN-γ horizon: biomarkers for immunodiagnosis of infection with Mycobacterium tuberculosis
Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M.
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …
Tuberculosis assays: past, present and future
Recent developments in the field of TB diagnostics, including the introduction of the Xpert
MTB/RIF assay in field testing, raise the hope for faster and more accurate identification of …
MTB/RIF assay in field testing, raise the hope for faster and more accurate identification of …
[HTML][HTML] Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report
Background Interferon gamma release assays, including the QuantiFERON ® TB Gold In
Tube (QFT) have been shown to be accurate in diagnosing Mycobacterium tuberculosis …
Tube (QFT) have been shown to be accurate in diagnosing Mycobacterium tuberculosis …
[HTML][HTML] Host blood RNA signatures predict the outcome of tuberculosis treatment
Biomarkers for tuberculosis treatment outcome will assist in guiding individualized treatment
and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of …
and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of …
Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs …
Background User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently
needed at points of care in resource-limited settings. We investigated host biomarkers …
needed at points of care in resource-limited settings. We investigated host biomarkers …
Hypercytokinaemia accompanies HIV–tuberculosis immune reconstitution inflammatory syndrome
…, K Matthews, R Seldon, NN Chegou… - European …, 2011 - Eur Respiratory Soc
Increased access to combination antiretroviral therapy in areas co-endemic for tuberculosis (TB)
and HIV-1 infection is associated with an increased incidence of immune reconstitution …
and HIV-1 infection is associated with an increased incidence of immune reconstitution …
[HTML][HTML] RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response
Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently
needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature…
needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature…
High level of discordant IGRA results in HIV-infected adults and children
…, AC Hesseling, NN Chegou… - … of Tuberculosis and …, 2008 - ingentaconnect.com
SETTING: Tygerberg district, Western Cape Province, South Africa.OBJECTIVE: To measure
the agreement of two interferon-gamma release assays (IGRAs) and the tuberculin skin test …
the agreement of two interferon-gamma release assays (IGRAs) and the tuberculin skin test …
[HTML][HTML] Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment …
… , van der Spuy G, Walzl G, Chegou NN. Host biomarkers detected in saliva show promise as
… , van der Spuy GD, Walzl G, Chegou NN. Differential expression of host biomarkers in saliva …
… , van der Spuy GD, Walzl G, Chegou NN. Differential expression of host biomarkers in saliva …