User profiles for N.L. Reynaert

Niki Reynaert

Maastricht University Medical Centre
Verified email at maastrichtuniversity.nl
Cited by 4632

Redox-sensitive kinases of the nuclear factor-κB signaling pathway

C Pantano, NL Reynaert, AVD Vliet… - Antioxidants & redox …, 2006 - liebertpub.com
NF-κB is an inducible transcription factor that plays a role in the expression of over one
hundred genes involved in immunity, inflammation, proliferation, and in defense against …

Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection?

EFM Wouters, NL Reynaert, MA Dentener… - Proceedings of the …, 2009 - atsjournals.org
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) and
probably asthma are associated with low-grade systemic inflammatory changes. In patients with …

Nuclear factor κB, airway epithelium, and asthma: avenues for redox control

…, C Pantano, JL Ather, NL Reynaert… - Proceedings of the …, 2009 - atsjournals.org
A wealth of recent studies points to the importance of airway epithelial cells in the orchestration
of inflammatory responses in the allergic inflamed lung. Studies also point to a role of …

Dynamic redox control of NF-κB through glutaredoxin-regulated S-glutathionylation of inhibitory κB kinase β

NL Reynaert, A van der Vliet… - Proceedings of the …, 2006 - National Acad Sciences
The transcription factor NF-κB, a central regulator of immunity, is subject to regulation by
redox changes. We now report that cysteine-179 of the inhibitory κB kinase (IKK) β-subunit of …

Nitric oxide represses inhibitory κB kinase through S-nitrosylation

NL Reynaert, K Ckless, SH Korn… - Proceedings of the …, 2004 - National Acad Sciences
Nitric oxide (NO) possesses antiinflammatory effects, which may be exerted via its ability to
inhibit the transcription factor, NF-κB. A commonly proposed mode of action for inhibition of …

[HTML][HTML] Silica induces NLRP3 inflammasome activation in human lung epithelial cells

…, EFM Wouters, BT Mossman, NL Reynaert - Particle and fibre …, 2013 - Springer
Background In myeloid cells the inflammasome plays a crucial role in innate immune defenses
against pathogen- and danger-associated patterns such as crystalline silica. Respirable …

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas

…, AS Guala, M Havermans, NL Reynaert… - Journal of cell …, 2009 - rupress.org
… with biotinylated glutathione ethyl ester as described previously (Reynaert et al., 2006),
and lysates … Janssen-Heininger and NL Reynaert have a patent application utilizing Grx-based …

[HTML][HTML] Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

…, PJA Borm, W Drommer, NL Reynaert… - Particle and fibre …, 2014 - Springer
Rationale Mineral particles in the lung cause inflammation and silicosis. In myeloid and
bronchial epithelial cells the inflammasome plays a role in responses to crystalline silica. …

Strong upregulation of AIM2 and IFI16 inflammasomes in the mucosa of patients with active inflammatory bowel disease

…, L Van Lommel, NL Reynaert… - Inflammatory bowel …, 2015 - academic.oup.com
Background Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of
the gut, partly driven by defects in the innate immune system. Considering the central role of …

Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential …

NL Reynaert, P Gopal, EPA Rutten… - The international journal …, 2016 - Elsevier
Age-related, non-communicable chronic inflammatory diseases represent the major 21st
century health problem. Especially in Western countries, the prevalence of non-communicable …