User profiles for N.A. Hanley

Neil Hanley

Pro-Vice Chancellor, Head of the College of Medical & Dental Sciences, University of …
Verified email at bham.ac.uk
Cited by 12250

[PDF][PDF] Steroidogenic factor 1: an essential mediator of endocrine development

…, M Bakke, L Zhao, C Frigeri, NA Hanley… - Recent progress in …, 2002 - Citeseer
The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP and officially
designated NR5A1) has emerged as an essential regulator of endocrine development and …

Human pancreas development

…, AA Berry, JP Strutt, DT Gerrard, NA Hanley - …, 2015 - journals.biologists.com
A wealth of data and comprehensive reviews exist on pancreas development in mammals,
primarily mice, and other vertebrates. By contrast, human pancreatic development has been …

[PDF][PDF] Assessing the safety of stem cell therapeutics

…, U Ben-David, R Eakins, N French, NA Hanley… - Cell stem cell, 2011 - cell.com
Unprecedented developments in stem cell research herald a new era of hope and expectation
for novel therapies. However, they also present a major challenge for regulators since …

Development of the human pancreas from foregut to endocrine commitment

…, J Blaylock, K Piper Hanley, NA Hanley - Diabetes, 2013 - Am Diabetes Assoc
Knowledge of human pancreas development underpins our interpretation and exploitation
of human pluripotent stem cell (PSC) differentiation toward a β-cell fate. However, almost no …

Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions

CE Forristal, KL Wright, NA Hanley… - Reproduction …, 2010 - rep.bioscientifica.com
Human embryonic stem (hES) cells are routinely cultured under atmospheric, 20% oxygen
tensions but are derived from embryos which reside in a 3–5% oxygen (hypoxic) environment…

Beta cell differentiation during early human pancreas development

…, SG Ball, DI Wilson, NA Hanley - Journal of …, 2004 - joe.bioscientifica.com
Understanding gene expression profiles during early human pancreas development is
limited by comparison to studies in rodents. In this study, from the inception of pancreatic …

[HTML][HTML] SRY, SOX9, and DAX1 expression patterns during human sex determination and gonadal development

NA Hanley, DM Hagan, M Clement-Jones… - Mechanisms of …, 2000 - Elsevier
SRY, SOX9, and DAX1 are key genes in human sex determination, by virtue of their associated
male-to-female sex reversal phenotypes when mutated (SRY, SOX9) or over-expressed (…

[HTML][HTML] Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

…, CE Goldring, KP Hanley, L Vallier, NA Hanley - Journal of …, 2015 - Elsevier
Background & Aims Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by
the use of soluble factors, can model human liver function and toxicity. However, at present …

Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alström syndrome

T Hearn, GL Renforth, C Spalluto, NA Hanley, K Piper… - Nature …, 2002 - nature.com
Alström syndrome (OMIM 203800) is an autosomal recessive disease, characterized by
cone–rod retinal dystrophy, cardiomyopathy and type 2 diabetes mellitus, that has been mapped …

[HTML][HTML] In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development

…, JI Mason, DI Wilson, NA Hanley - The Journal of …, 2006 - Am Soc Clin Investig
Male and female external genitalia appear identical early in gestation. Testosterone
exposure at 8–12 weeks’ gestation causes male differentiation. Female fetuses virilize if their …