Pneumococcal infections elicited by Streptococcus pneumoniae (pneumococcus) (pneumonia,
otitis media, sinusitis, meningitis) are frequently occurring diseases that are associated …

… Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more
symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 …

The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound
IL-6 receptor (mIL-6R) or the soluble IL-6 receptor (sIL-6R) and glycoprotein 130 (gp130). In …

Background The most prevalent phenotype of asthma is characterized by eosinophil-dominated
inflammation that is driven by a type 2 helper T cell (Th2). Therapeutic targeting of …

Background Asthma is a heterogeneous disease in which there is a differential response to
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …

… This reduces the degree of variation and the number of volunteers (n = 12). In the previous
… concentrated ambient air particles from Chapel Hill, North Carolina that ranged from 23–311 …

Atopic asthma is characterized by bronchial mucosal inflammation, involving eosinophils,
mast cells, and lymphocytes. It has been suggested that the development and maintenance of …

Background The loss of alveolar walls is a hallmark of emphysema. As fibroblasts play an
important role in the maintenance of alveolar structure, a change in fibroblast phenotype could …

Background Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R)
to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in …

Inhalation is a non-invasive approach for both local and systemic drug delivery. This study
aimed to define the therapeutic window for solid lipid nanoparticles (SLNs) as a drug delivery …