Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

…, MM Nöthen, S Moebus, KH Jöckel, N Klopp… - Nature …, 2009 - nature.com
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

…, PRV Johnson, T Jørgensen, WHL Kao, N Klopp… - Nature …, 2010 - nature.com
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

…, MM Nöthen, S Moebus, KH Jöckel, N Klopp… - Nature …, 2011 - nature.com
We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

Large-scale association analysis identifies new risk loci for coronary artery disease

…, Y Jang, M Kähönen, F Kee, HS Kim, N Klopp… - Nature …, 2013 - nature.com
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

Defining the role of common variation in the genomic and biological architecture of adult human height

…, J Junttila, AN Kho, L Kinnunen, N Klopp… - Nature …, 2014 - nature.com
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

Common variants associated with plasma triglycerides and risk for coronary artery disease

…, P Kaleebu, JJP Kastelein, KT Khaw, E Kim, N Klopp… - Nature …, 2013 - nature.com
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery …

Identification of seven loci affecting mean telomere length and their association with disease

…, L Kananen, LC Karssen, J Kettunen, N Klopp… - Nature …, 2013 - nature.com
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

New loci associated with kidney function and chronic kidney disease

…, S Wilde, TF Munzel, TS Leak, T Illig, N Klopp… - Nature …, 2010 - nature.com
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies
have identified common CKD susceptibility variants. The CKDGen consortium performed …

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

…, HL Kim, S Kim, YJ Kim, L Kinnunen, N Klopp - Nature …, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS), including …

[PDF][PDF] A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

…, EC Schulte, P Lichtner, SC Rossle, N Klopp… - The American Journal of …, 2011 - cell.com
To identify rare causal variants in late-onset Parkinson disease (PD), we investigated an
Austrian family with 16 affected individuals by exome sequencing. We found a missense …