Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
…, MM Nöthen, S Moebus, KH Jöckel, N Klopp… - Nature …, 2009 - nature.com
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
…, PRV Johnson, T Jørgensen, WHL Kao, N Klopp… - Nature …, 2010 - nature.com
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…
and 38,987 controls of European descent and following up previously unidentified meta-…
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
…, MM Nöthen, S Moebus, KH Jöckel, N Klopp… - Nature …, 2011 - nature.com
We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …
Large-scale association analysis identifies new risk loci for coronary artery disease
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …
Defining the role of common variation in the genomic and biological architecture of adult human height
…, J Junttila, AN Kho, L Kinnunen, N Klopp… - Nature …, 2014 - nature.com
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …
significance that together explained one-fifth of the heritability for adult height. By testing …
Common variants associated with plasma triglycerides and risk for coronary artery disease
…, P Kaleebu, JJP Kastelein, KT Khaw, E Kim, N Klopp… - Nature …, 2013 - nature.com
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery …
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery …
Identification of seven loci affecting mean telomere length and their association with disease
…, L Kananen, LC Karssen, J Kettunen, N Klopp… - Nature …, 2013 - nature.com
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
New loci associated with kidney function and chronic kidney disease
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies
have identified common CKD susceptibility variants. The CKDGen consortium performed …
have identified common CKD susceptibility variants. The CKDGen consortium performed …
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS), including …
aggregated published meta-analyses of genome-wide association studies (GWAS), including …
[PDF][PDF] A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease
…, EC Schulte, P Lichtner, SC Rossle, N Klopp… - The American Journal of …, 2011 - cell.com
To identify rare causal variants in late-onset Parkinson disease (PD), we investigated an
Austrian family with 16 affected individuals by exome sequencing. We found a missense …
Austrian family with 16 affected individuals by exome sequencing. We found a missense …