User profiles for N. Aceto

Nicola Aceto

Associate Professor of Molecular Oncology, ETH Zurich
Verified email at biol.ethz.ch
Cited by 11543

[HTML][HTML] Biology, vulnerabilities and clinical applications of circulating tumour cells

A Ring, BD Nguyen-Sträuli, A Wicki, N Aceto - Nature Reviews Cancer, 2023 - nature.com
In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading to …

En route to metastasis: circulating tumor cell clusters and epithelial-to-mesenchymal transition

N Aceto, M Toner, S Maheswaran, DA Haber - Trends in cancer, 2015 - cell.com
Blood-borne metastasis accounts for the vast majority of cancer-related deaths and it is fueled
by the generation of circulating tumor cells (CTCs) from a primary tumor deposit. Recent …

[HTML][HTML] Tracking cancer progression: From circulating tumor cells to metastasis

F Castro-Giner, N Aceto - Genome Medicine, 2020 - Springer
The analysis of circulating tumor cells (CTCs) is an outstanding tool to provide insights into
the biology of metastatic cancers, to monitor disease progression and with potential for use in …

[HTML][HTML] Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis

N Aceto, A Bardia, DT Miyamoto, MC Donaldson… - Cell, 2014 - cell.com
… We observed a mean of 2,486 CTC events per mouse (n = 5 mice), of which a mean of
65 (2.6%) were CTC clusters and 2,421 (97.4%) were single CTCs (Figures 1B, 1C, and S2A). …

Neutrophils escort circulating tumour cells to enable cell cycle progression

…, C Rochlitz, WP Weber, N Beerenwinkel, N Aceto - Nature, 2019 - nature.com
… breast cancer (n = 9 for patients with one or more CTC–neutrophil clusters and n = 10 for …
on the manuscript, and all members of the Aceto laboratory for feedback and discussions; K. …

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

M Yu, A Bardia, N Aceto, F Bersani, MW Madden… - science, 2014 - science.org
… (D) Response of BRx-07 CTC-derived mouse xenografts to the PI3K inhibitor BYL719 (n
= 4), the FGFR2 inhibitor AZD4547 (n = 3), the combination of the two inhibitors (BYL719+…

A microfluidic device for label-free, physical capture of circulating tumor cell clusters

AF Sarioglu, N Aceto, N Kojic, MC Donaldson… - Nature …, 2015 - nature.com
… In a subset of our patient cohort (n = 19), we compared the number of CTC clusters captured
using the Cluster-Chip with the number of single CTCs simultaneously identified using CTC-…

E-cadherin is required for metastasis in multiple models of breast cancer

V Padmanaban, I Krol, Y Suhail, BM Szczerba, N Aceto… - Nature, 2019 - nature.com
… We then assayed the effects of the anti-oxidant N-acetyl cysteine (NAC) 21 . NAC had no
significant effect on dissemination of control or E-cad − cells into collagen I. However, NAC …

[PDF][PDF] Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding

…, C Rochlitz, WP Weber, N Aceto - Cell, 2019 - cell.com
n = 151 for green; n = 2 for yellow expression module) (Figures 4F and 4G; Table S4), in
high concordance (85% overlap) with patient-derived modules enriched in CTC clusters (Figure …

[PDF][PDF] Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells

…, NV Jordan, AM Shah, DT Miyamoto, N Aceto… - Cell reports, 2014 - cell.com
Circulating tumor cells (CTCs) are shed from primary tumors into the bloodstream, mediating
the hematogenous spread of cancer to distant organs. To define their composition, we …