[HTML][HTML] Artemisinin-resistant Plasmodium falciparum with high survival rates, Uganda, 2014–2016

…, M Yamauchi, M Sekihara, M Hashimoto… - Emerging infectious …, 2018 - ncbi.nlm.nih.gov
Because≈ 90% of malaria cases occur in Africa, emergence of artemisinin-resistant
Plasmodium falciparum in Africa poses a serious public health threat. To assess emergence of …

Synthesis of palmitoyl derivatives of insulin and their biological activities

M Hashimoto, K Takada, Y Kiso, S Muranishi - Pharmaceutical research, 1989 - Springer
In order to improve the lipophilicity of peptides, bovine insulin was chosen for the chemical
modification using palmitic acid. The N-hydroxysuccinimide ester of palmitic acid was used …

[HTML][HTML] Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor

…, F Nurwidya, I Kobayashi, K Minakata, M Hashimoto… - PloS one, 2014 - journals.plos.org
Accumulating evidence indicates that a small population of cancer stem cells (CSCs) is
involved in intrinsic resistance to cancer treatment. The hypoxic microenvironment is an …

Sodium-doped carbon nitride nanotubes for efficient visible light-driven hydrogen production

L Zhang, N Ding, M Hashimoto, K Iwasaki, N Chikamori… - Nano Research, 2018 - Springer
Sodium-doped carbon nitride nanotubes (Na x -CNNTs) were prepared by a green and
simple two-step method and applied in photocatalytic water splitting for the first time. …

Hypoxia induces gefitinib resistance in non‐small‐cell lung cancer with both mutant and wild‐type epidermal growth factor receptors

K Minakata, F Takahashi, T Nara, M Hashimoto… - Cancer …, 2012 - Wiley Online Library
Somatic mutations in the epidermal growth factor receptor ( EGFR ) gene, such as exon 19
deletion mutations, are important factors in determining therapeutic responses to gefitinib in …

Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells

…, F Takahashi, F Nurwidya, T Nara, M Hashimoto… - Biochemical and …, 2016 - Elsevier
Several recent studies have suggested that cancer stem cells (CSCs) are involved in
resistance to gefitinib in non-small cell lung cancer (NSCLC). Oct4, a member of the POU-domain …

A supramolecular photocatalyst composed of a polyoxometalate and a photosensitizing water-soluble porphyrin diacid for the oxidation of organic substrates in water

T Ishizuka, S Ohkawa, H Ochiai, M Hashimoto… - Green chemistry, 2018 - pubs.rsc.org
A diprotonated form of a cationic water-soluble saddle-distorted porphyrin (H416+) forms
stable supramolecular assemblies with multianionic polyoxometalates (POMs) by electrostatic …

Inositol 1,4,5‐trisphosphate receptor regulates replication, differentiation, infectivity and virulence of the parasitic protist Trypanosoma cruzi

M Hashimoto, M Enomoto, J Morales… - Molecular …, 2013 - Wiley Online Library
In animals, inositol 1,4,5‐trisphosphate receptors ( IP 3 Rs ) are ion channels that play a
pivotal role in many biological processes by mediating Ca 2+ release from the endoplasmic …

[HTML][HTML] Development of a quantitative, portable, and automated fluorescent blue-ray device-based malaria diagnostic equipment with an on-disc SiO2 nanofiber filter

T Yamamoto, M Hashimoto, K Nagatomi, T Nogami… - Scientific reports, 2020 - nature.com
There is an urgent need to develop an automated malaria diagnostic system that can easily
and rapidly detect malaria parasites and determine the proportion of malaria-infected …

Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial–mesenchymal transition in non-small cell lung cancer

…, M Kato, K Minakata, T Nara, M Hashimoto… - Biochemical and …, 2014 - Elsevier
Insulin-like growth factor 1 receptor (IGF1R) is expressed in many types of solid tumors
including non-small cell lung cancer (NSCLC), and enhanced activation of IGF1R is thought to …