Exposure of platelets to shear stress leads to aggregation in the absence of exogenous
agonists. We have now found that different adhesive proteins and platelet membrane …

Objective: Resistin is associated with insulin resistance in mice and may play a similar role
in humans. The aim of our study was to examine the relationship of serum resistin level to …

Importance Prevention of atherosclerotic cardiovascular diseases is an important public
health priority in Japan due to an aging population. Objective To determine whether daily, low-…

The common 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism
causes decreased activity of this enzyme and can be associated with mild-to-moderate …

Upshaw–Schulman syndrome (USS) is an extremely rare hereditary deficiency of ADAMTS13
activity, termed congenital TTP. The clinical signs are usually mild during childhood, often …

Upshaw–Schulman syndrome (USS) is a congenital thrombotic thrombocytopenic purpura (TTP)
due to mutations in the gene that encodes for ADAMTS13 (ADAMTS13), but its clinical …

Recent reports have suggested that polymorphisms in the human paraoxonase (HUMPONA)
gene may be a genetic risk factor for coronary artery disease (CAD) in white populations. …

INTRODUCTION: Genetic deficiencies of PROS1, PROC, and SERPINC1 (antithrombin) are
risk factors for deep vein thrombosis (DVT). Diagnosis of the inherited deficiencies of these …

The hemostatic activity of von Willebrand factor (vWF) is strongly dependent on its multimeric
structure, with the highest activity in ‘unusually large’ multimers secreted from endothelial …

Thrombotic thrombocytopenic purpura (TTP) can rapidly progress into a life-threatening
condition, thus the importance of appropriate diagnosis and treatment cannot be overstated. …