User profiles for Miquéias Lopes-Pacheco
Miquéias Lopes-PachecoEmory University School of Medicine Verified email at emory.edu Cited by 2568 |
[HTML][HTML] CFTR modulators: the changing face of cystic fibrosis in the era of precision medicine
M Lopes-Pacheco - Frontiers in pharmacology, 2020 - frontiersin.org
Cystic fibrosis (CF) is a lethal inherited disease caused by mutations in the CF transmembrane
conductance regulator (CFTR) gene, which result in impairment of CFTR mRNA and …
conductance regulator (CFTR) gene, which result in impairment of CFTR mRNA and …
[HTML][HTML] Laboratory biomarkers for diagnosis and prognosis in COVID-19
D Battaglini, M Lopes-Pacheco… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes a wide spectrum
of clinical manifestations, with progression to multiorgan failure in the most severe cases. …
of clinical manifestations, with progression to multiorgan failure in the most severe cases. …
[HTML][HTML] CFTR modulators: shedding light on precision medicine for cystic fibrosis
M Lopes-Pacheco - Frontiers in pharmacology, 2016 - frontiersin.org
Cystic fibrosis (CF) is the most common life-threatening monogenic disease afflicting Caucasian
people. It affects the respiratory, gastrointestinal, glandular and reproductive systems. …
people. It affects the respiratory, gastrointestinal, glandular and reproductive systems. …
[HTML][HTML] Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema
…, FF Cruz, AC Teixeira, M Lopes-Pacheco… - Respiratory …, 2014 - Springer
We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung
inflammation and remodeling in experimental emphysema would differ according to MSC source …
inflammation and remodeling in experimental emphysema would differ according to MSC source …
[HTML][HTML] Pathogenesis of multiple organ injury in COVID-19 and potential therapeutic strategies
M Lopes-Pacheco, PL Silva, FF Cruz… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory disease coronavirus 2 (SARS-CoV-2, formerly 2019-nCoV) is a
novel coronavirus that has rapidly disseminated worldwide, causing the coronavirus disease …
novel coronavirus that has rapidly disseminated worldwide, causing the coronavirus disease …
[HTML][HTML] Cell-based therapy for silicosis
M Lopes-Pacheco, E Bandeira, MM Morales - Stem cells …, 2016 - hindawi.com
Silicosis is the most common pneumoconiosis globally, with higher prevalence and incidence
in developing countries. To date, there is no effective treatment to halt or reverse the …
in developing countries. To date, there is no effective treatment to halt or reverse the …
Current understanding of the immunosuppressive properties of mesenchymal stromal cells
LL de Castro, M Lopes-Pacheco, DJ Weiss… - Journal of Molecular …, 2019 - Springer
Several studies have demonstrated the anti-inflammatory potential of mesenchymal stromal
cells (MSCs) isolated from bone marrow, adipose tissue, placenta, and other sources. …
cells (MSCs) isolated from bone marrow, adipose tissue, placenta, and other sources. …
Discovery of CFTR modulators for the treatment of cystic fibrosis
M Lopes-Pacheco, N Pedemonte… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction Cystic fibrosis (CF) is a life-threatening inherited disease caused by mutations in
the gene encoding the CF transmembrane conductance regulator (CFTR) protein, an anion …
the gene encoding the CF transmembrane conductance regulator (CFTR) protein, an anion …
[HTML][HTML] Mesenchymal stromal cell-derived extracellular vesicles in lung diseases: current status and perspectives
SC Abreu, M Lopes-Pacheco, DJ Weiss… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) have emerged as a potential therapy for several diseases. These
plasma membrane-derived fragments are released constitutively by virtually all cell types—…
plasma membrane-derived fragments are released constitutively by virtually all cell types—…
[HTML][HTML] Dasatinib reduces lung inflammation and fibrosis in acute experimental silicosis
Silicosis is an occupational lung disease with no effective treatment. We hypothesized that
dasatinib, a tyrosine kinase inhibitor, might exhibit therapeutic efficacy in silica-induced …
dasatinib, a tyrosine kinase inhibitor, might exhibit therapeutic efficacy in silica-induced …