Thrombin and phenotypic modulation of the endothelium

T Minami, A Sugiyama, SQ Wu, R Abid… - … , and vascular biology, 2004 - Am Heart Assoc
Thrombin signaling in the endothelium is linked to multiple phenotypic changes, including
alterations in permeability, vasomotor tone, and leukocyte trafficking. The thrombin signal is …

Endothelial cell gene regulation

T Minami, WC Aird - Trends in cardiovascular medicine, 2005 - Elsevier
Endothelial cells (ECs) display phenotypic heterogeneity. Endothelial cell heterogeneity is
mediated, at least in part, by site-specific and time-dependent differences in gene transcription…

[HTML][HTML] Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

…, M Ohmura, A Kubo, M Suematsu, K Takahashi… - Nature …, 2012 - nature.com
In cancer metastasis, various environmental stressors attack the disseminating cells. The
successful colonization of cancer cells in secondary sites therefore requires the ability of the …

Sintering inhibition mechanism of platinum supported on ceria-based oxide and Pt-oxide–support interaction

…, T Hirabayashi, K Dohmae, N Takagi, T Minami… - Journal of …, 2006 - Elsevier
Sintering inhibition mechanism of Pt in Pt/ceria-based oxide catalyst under oxidizing
condition at high temperature was studied by several analysis techniques. Pt in a Pt/ceria-based …

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

S Fukuhara, K Sako, T Minami, K Noda, HZ Kim… - Nature cell …, 2008 - nature.com
Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1
(Ang1). Gene-targeting analyses of either Ang1 or Tie2 in mice reveal a critical role of …

Tumor cell–derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis

…, T Ito, Y Yamamoto, T Minami, S Okada, T Takahashi… - Cancer research, 2012 - AACR
Strategies to inhibit metastasis have been mainly unsuccessful in part due to insufficient
mechanistic understanding. Here, we report evidence of critical role for the angiopoietin-like …

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

…, RJ Siarey, MW Lensch, IH Park, SS Yoon, T Minami… - Nature, 2009 - nature.com
The incidence of many cancer types is significantly reduced in individuals with Down’s
syndrome 1 , 2 , 3 , 4 , and it is thought that this broad cancer protection is conferred by the …

Role of Endothelial Cell–Derived Angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression

…, M Tabata, H Tazume, Z Tian, O Takahashi… - … , and vascular biology, 2014 - Am Heart Assoc
Objective— Cardiovascular disease (CVD), the most common morbidity resulting from
atherosclerosis, remains a frequent cause of death. Efforts to develop effective therapeutic …

A simple method of isolating mouse aortic endothelial cells

M Kobayashi, K Inoue, E Warabi, T Minami… - … of atherosclerosis and …, 2005 - jstage.jst.go.jp
In the study of vascular biology, analyses of endothelial cells (EC) and smooth muscle cells (SMC)
are very important. The mouse is a critical model for research, however, the isolation …

Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells

MR Abid, S Guo, T Minami, KC Spokes… - … , and vascular biology, 2004 - Am Heart Assoc
Objective— Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor
that promotes endothelial cell (EC) survival, migration, and permeability. The forkhead …