Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour
types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in non-…

Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4 (GPX4).
At present, mechanisms that could predict sensitivity and/or resistance and that may …

Selenoproteins are rare proteins among all kingdoms of life containing the 21 st amino acid,
selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of …

MALDI Imaging mass spectrometry has entered the field of tissue-based research by providing
unique advantages for analyzing tissue specimen in an unprecedented detail. A broad …

Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or
dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion …

Formalin-fixed and paraffin-embedded (FFPE) tissue specimens are the gold standard for
histological examination, and they provide valuable molecular information in tissue-based …

Background & Aims Antiviral agents suppress hepatitis B virus (HBV) replication but do not
clear the infection. A strong effector T-cell response is required to eradicate HBV, but this …

We present the first analytical approach to demonstrate the in situ imaging of metabolites
from formalin‐fixed, paraffin‐embedded ( FFPE ) human tissue samples. Using high‐resolution …

Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular
matrix, in particular, collagens. Two IPF therapeutics, nintedanib and pirfenidone, decelerate …

Pancreatic ductal adenocarcinoma (PDAC) and its precursor lesions, pancreatic intraepithelial
neoplasia (PanIN), display a ductal phenotype. However, there is evidence in genetically …