User profiles for Michael Segel
Michael Segelpostdoctoral fellow, Broad Institute Verified email at broadinstitute.org Cited by 6129 |
[HTML][HTML] Detection of SARS-CoV-2 with SHERLOCK one-pot testing
Detection of SARS-CoV-2 with a CRISPR-Based Test A new method for the detection of
SARS-CoV-2 combines simplified extraction of RNA with isothermal amplification and CRISPR (…
SARS-CoV-2 combines simplified extraction of RNA with isothermal amplification and CRISPR (…
Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery
Eukaryotic genomes contain domesticated genes from integrating viruses and mobile
genetic elements. Among these are homologs of the capsid protein (known as Gag) of long …
genetic elements. Among these are homologs of the capsid protein (known as Gag) of long …
[PDF][PDF] Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes
Microglia, the resident immune cells of the brain, rapidly change states in response to their
environment, but we lack molecular and functional signatures of different microglial …
environment, but we lack molecular and functional signatures of different microglial …
Niche stiffness underlies the ageing of central nervous system progenitor cells
Ageing causes a decline in tissue regeneration owing to a loss of function of adult stem cell
and progenitor cell populations 1 . One example is the deterioration of the regenerative …
and progenitor cell populations 1 . One example is the deterioration of the regenerative …
Diverse enzymatic activities mediate antiviral immunity in prokaryotes
Bacteria and archaea are frequently attacked by viruses and other mobile genetic elements
and rely on dedicated antiviral defense systems, such as restriction endonucleases and …
and rely on dedicated antiviral defense systems, such as restriction endonucleases and …
Remyelination and ageing: reversing the ravages of time
Remyelination is a neuroprotective regenerative response to demyelination that restores
saltatory conduction and decreases the vulnerability of axons to irreversible degeneration. It is …
saltatory conduction and decreases the vulnerability of axons to irreversible degeneration. It is …
[HTML][HTML] Generation of functional human pancreatic β cells in vitro
FW Pagliuca, JR Millman, M Gürtler, M Segel… - Cell, 2014 - cell.com
The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide
an unprecedented cell source for drug discovery and cell transplantation therapy in diabetes…
an unprecedented cell source for drug discovery and cell transplantation therapy in diabetes…
[HTML][HTML] Point-of-care testing for COVID-19 using SHERLOCK diagnostics
The recent outbreak of the novel coronavirus SARS-CoV-2, which causes COVID-19, can be
diagnosed using RT-qPCR, but inadequate access to reagents and equipment has slowed …
diagnosed using RT-qPCR, but inadequate access to reagents and equipment has slowed …
[PDF][PDF] Metformin restores CNS remyelination capacity by rejuvenating aged stem cells
The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs)
is associated with irreversible neurodegeneration in multiple sclerosis (MS). …
is associated with irreversible neurodegeneration in multiple sclerosis (MS). …
Smoke and autoimmunity: The fire behind the disease
…, M Versini, D Ben-Ami, S Gertel, A Watad, MJ Segel… - Autoimmunity …, 2016 - Elsevier
The association between smoke habit and autoimmunity has been hypothesized a long time
ago. Smoke has been found to play a pathogenic role in certain autoimmune disease as it …
ago. Smoke has been found to play a pathogenic role in certain autoimmune disease as it …