User profiles for Michael Segel

Michael Segel

postdoctoral fellow, Broad Institute
Verified email at broadinstitute.org
Cited by 6129

[HTML][HTML] Detection of SARS-CoV-2 with SHERLOCK one-pot testing

…, M Saito, NG Kim, AE Woolley, M Segel… - … England Journal of …, 2020 - Mass Medical Soc
Detection of SARS-CoV-2 with a CRISPR-Based Test A new method for the detection of
SARS-CoV-2 combines simplified extraction of RNA with isothermal amplification and CRISPR (…

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery

M Segel, B Lash, J Song, A Ladha, CC Liu, X Jin… - Science, 2021 - science.org
Eukaryotic genomes contain domesticated genes from integrating viruses and mobile
genetic elements. Among these are homologs of the capsid protein (known as Gag) of long …

[PDF][PDF] Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes

…, A Young, A Wysoker, AJ Walker, F Gergits, M Segel… - Immunity, 2019 - cell.com
Microglia, the resident immune cells of the brain, rapidly change states in response to their
environment, but we lack molecular and functional signatures of different microglial …

Niche stiffness underlies the ageing of central nervous system progenitor cells

M Segel, B Neumann, MFE Hill, IP Weber, C Viscomi… - Nature, 2019 - nature.com
Ageing causes a decline in tissue regeneration owing to a loss of function of adult stem cell
and progenitor cell populations 1 . One example is the deterioration of the regenerative …

Diverse enzymatic activities mediate antiviral immunity in prokaryotes

L Gao, H Altae-Tran, F Böhning, KS Makarova, M Segel… - Science, 2020 - science.org
Bacteria and archaea are frequently attacked by viruses and other mobile genetic elements
and rely on dedicated antiviral defense systems, such as restriction endonucleases and …

Remyelination and ageing: reversing the ravages of time

B Neumann, M Segel, KJ Chalut… - Multiple Sclerosis …, 2019 - journals.sagepub.com
Remyelination is a neuroprotective regenerative response to demyelination that restores
saltatory conduction and decreases the vulnerability of axons to irreversible degeneration. It is …

[HTML][HTML] Generation of functional human pancreatic β cells in vitro

FW Pagliuca, JR Millman, M Gürtler, M Segel… - Cell, 2014 - cell.com
The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide
an unprecedented cell source for drug discovery and cell transplantation therapy in diabetes…

[HTML][HTML] Point-of-care testing for COVID-19 using SHERLOCK diagnostics

J Joung, A Ladha, M Saito, M Segel, R Bruneau… - MedRxiv, 2020 - ncbi.nlm.nih.gov
The recent outbreak of the novel coronavirus SARS-CoV-2, which causes COVID-19, can be
diagnosed using RT-qPCR, but inadequate access to reagents and equipment has slowed …

[PDF][PDF] Metformin restores CNS remyelination capacity by rejuvenating aged stem cells

B Neumann, R Baror, C Zhao, M Segel, S Dietmann… - Cell stem cell, 2019 - cell.com
The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs)
is associated with irreversible neurodegeneration in multiple sclerosis (MS). …

Smoke and autoimmunity: The fire behind the disease

…, M Versini, D Ben-Ami, S Gertel, A Watad, MJ Segel… - Autoimmunity …, 2016 - Elsevier
The association between smoke habit and autoimmunity has been hypothesized a long time
ago. Smoke has been found to play a pathogenic role in certain autoimmune disease as it …