Wiskott-Aldrich syndrome (WAS) is characterized by microthrombocytopenia, immunodeficiency,
autoimmunity, and susceptibility to malignancies. In our hematopoietic stem cell gene …

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) protect against cardiovascular
disease by largely unknown mechanisms. We tested the hypothesis that EPA and DHA …

The relative contribution of the effector molecules produced by T cells to tumour rejection is
unclear, but interferon-γ (IFNγ) is critical in most of the analysed models 1 . Although IFNγ …

Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA) contribute to the
regulation of cardiovascular function. CYP enzymes also accept EPA and DHA to yield more …

Liver tumors, particularly hepatocellular carcinoma (HCC), are a major cause of morbidity
and mortality worldwide. The development of HCC is mostly associated with chronic …

Retroviral integrase (IN) proteins catalyze the permanent integration of proviral genomes
into host DNA with the help of cellular cofactors. Lens epithelium-derived growth factor (LEDGF…

The genomic analysis of Streptococcus pneumoniae strains identified the Pneumococcal
adherence and virulence factor B (PavB), whose repetitive sequences, designated …

Fetal liver progenitor cell suspensions (FLPC) and hepatic precursor cells derived from
embryonic stem cells (ES-HPC) represent a potential source for liver cell therapy. However, the …

A previously published clinical trial demonstrated the benefit of autologous CD34+ cells
transduced with a selfinactivating lentiviral vector (HPV569) containing an engineered β-globin …

Cells adapt to temperature shifts by adjusting levels of lipid desaturation and membrane
fluidity. This fundamental process occurs in nearly all forms of life, but its mechanism in …