User profiles for Michael Portelli
 | Michael PortelliUniversity of Nottingham Verified email at nottingham.ac.uk Cited by 1065 |
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association discovery …
and is the third leading cause of death globally. Through genome-wide association discovery …
Genetic risk factors for the development of allergic disease identified by genome‐wide association
MA Portelli, E Hodge, I Sayers - Clinical & Experimental Allergy, 2015 - Wiley Online Library
An increasing proportion of the worldwide population is affected by allergic diseases such
as allergic rhinitis (AR), atopic dermatitis (AD) and allergic asthma and improved treatment …
as allergic rhinitis (AR), atopic dermatitis (AD) and allergic asthma and improved treatment …
[HTML][HTML] Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study
Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed
to identity novel genetic variants associated with moderate-to-severe asthma, see whether …
to identity novel genetic variants associated with moderate-to-severe asthma, see whether …
Phenotypic and functional translation of IL33 genetics in asthma
ME Ketelaar, MA Portelli, FN Dijk, N Shrine… - Journal of Allergy and …, 2021 - Elsevier
Background Asthma is a complex disease with multiple phenotypes that may differ in disease
pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have …
pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have …
Genetic basis for personalized medicine in asthma
M Portelli, I Sayers - Expert review of respiratory medicine, 2012 - Taylor & Francis
There is heterogeneity in patient responses to current asthma medications. Significant
progress has been made identifying genetic polymorphisms that influence the efficacy and …
progress has been made identifying genetic polymorphisms that influence the efficacy and …
[HTML][HTML] Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium
MA Portelli, FN Dijk, ME Ketelaar, N Shrine… - JCI insight, 2020 - ncbi.nlm.nih.gov
The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution
of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the …
of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the …
[HTML][HTML] Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction
Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and
mortality and, whilst smoking remains the single most important risk factor, COPD risk is …
mortality and, whilst smoking remains the single most important risk factor, COPD risk is …
[HTML][HTML] Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels
MA Portelli, M Siedlinski, CE Stewart… - The FASEB …, 2014 - ncbi.nlm.nih.gov
The soluble cleaved urokinase plasminogen activator receptor (scuPAR) is a circulating
protein detected in multiple diseases, including various cancers, cardiovascular disease, and …
protein detected in multiple diseases, including various cancers, cardiovascular disease, and …
Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity
Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated
in the airway epithelium in asthma; however, the contribution of uPAR to asthma …
in the airway epithelium in asthma; however, the contribution of uPAR to asthma …
Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients
MA Portelli, C Moseley, CE Stewart, DS Postma… - Allergy, 2017 - Wiley Online Library
Rationale Genetic polymorphisms in the asthma susceptibility gene, urokinase plasminogen
activator receptor (u PAR / PLAUR ) have been associated with lung function decline and u …
activator receptor (u PAR / PLAUR ) have been associated with lung function decline and u …