[HTML][HTML] The SGLT2 inhibitor empagliflozin improves cardiac energy status via mitochondrial ATP production in diabetic mice

…, A Oomachi, Y Kotobuki, Y Nishiya, MP Pieper… - Communications …, 2023 - nature.com
Empagliflozin, a sodium-glucose co-transporter 2 inhibitor developed, has been shown to
reduce cardiovascular events in patients with type 2 diabetes and established cardiovascular …

Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism

…, F Pompeo, L Riccobono, MP Pieper… - European journal of …, 2008 - Elsevier
Acetylcholine may play a role in cell activation and airway inflammation. We evaluated the
levels of both mRNA and protein of muscarinic M 1 , M 2 , M 3 receptors in human bronchial …

[HTML][HTML] Enhanced cardiorenal protective effects of combining SGLT2 inhibition, endothelin receptor antagonism and RAS blockade in type 2 diabetic mice

…, MM Van den Bosch, S Bermejo, MP Pieper… - International journal of …, 2022 - mdpi.com
Treatments with sodium–glucose 2 cotransporter inhibitors (SGLT2i) or endothelin receptor
antagonists (ERA) have shown cardiorenal protective effects. The present study aimed to …

Molecular basis for the long duration of action and kinetic selectivity of tiotropium for the muscarinic M3 receptor

…, F Gantner, MP Pieper, P Casarosa - Journal of medicinal …, 2013 - ACS Publications
Antagonizing the human M3 muscarinic receptor (hM3R) over a long time is a key feature of
modern bronchodilating COPD drugs aiming at symptom relief. The long duration of action …

Smoke, choline acetyltransferase, muscarinic receptors, and fibroblast proliferation in chronic obstructive pulmonary disease

…, L Riccobono, P Casarosa, MP Pieper… - … of Pharmacology and …, 2009 - ASPET
Acetylcholine (ACh), synthesized by choline acetyltransferase (ChAT), and muscarinic M 1 ,
M 2 , and M 3 receptors (MRs) are involved in fibroblast proliferation. We evaluated ChAT, …

[HTML][HTML] β2 long-acting and anticholinergic drugs control TGF-β1-mediated neutrophilic inflammation in COPD

…, L Siena, M Ferraro, P Casarosa, MP Pieper… - … et Biophysica Acta (BBA …, 2012 - Elsevier
We quantified TGF-β1 and acetylcholine (ACh) concentrations in induced sputum supernatants
(ISSs) from 18 healthy controls (HC), 22 healthy smokers (HS) and 21 COPDs. ISSs from …

COVID-19 promotes endothelial dysfunction and thrombogenicity: role of proinflammatory cytokines/SGLT2 prooxidant pathway

…, O Vollmer, JM Lessinger, N Meyer, MP Pieper… - Journal of Thrombosis …, 2024 - Elsevier
Background COVID-19 is associated with an increased risk of cardiovascular complications.
Although cytokines have a predominant role in endothelium damage, the precise molecular …

[HTML][HTML] The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease

…, MR Dowling, SJ Charlton, MP Pieper… - Current opinion in …, 2014 - Elsevier
… Author links open overlay panel Philippa R Dale 1 7 , Hana Cernecka 2 3 7 , Martina
Schmidt 2 3 , Mark R Dowling 4 , Steven J Charlton 4 , Michael P Pieper 5 , Martin C Michel 5 6 …

Cigarette smoke extract activates human bronchial epithelial cells affecting non-neuronal cholinergic system signalling in vitro

…, S Girbino, GD Albano, P Casarosa, MP Pieper… - Life sciences, 2011 - Elsevier
… The conflict of interest involve Paola Casarosa and Michael P. Pieper employers of
Boehriger Ingelheim although they did not partecipate in the data analysis and intrpretations. …

IL-17A induces chromatin remodeling promoting IL-8 release in bronchial epithelial cells: effect of Tiotropium

…, AM Montalbano, A Bonanno, L Riccobono, MP Pieper… - Life sciences, 2016 - Elsevier
Aims IL-17A plays a key role in the persistence of airway inflammation, oxidative stress, and
reduction of steroid-sensitivity in COPD. We studied the effect of IL-17A on chromatin …