User profiles for Metin Aytekin

Doç. Dr. Metin Aytekin

Cleveland Clinic
Verified email at metinaytekin.com
Cited by 1619

Antioxidant effects of methionine, α-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats

E Caylak, M Aytekin, I Halifeoglu - Experimental and Toxicologic Pathology, 2008 - Elsevier
Lead, widely used in industry, is a great environmental health problem. Many studies have
examined its effects on the health of both humans and animals. Experimental studies have …

Plasma levels of high-density lipoprotein cholesterol and outcomes in pulmonary arterial hypertension

GA Heresi, M Aytekin, J Newman… - American journal of …, 2010 - atsjournals.org
Rationale: High-density lipoprotein cholesterol (HDL-C) promotes healthy vascular function,
and it is decreased in insulin resistance. Insulin resistance predisposes to pulmonary …

High levels of hyaluronan in idiopathic pulmonary arterial hypertension

M Aytekin, SAA Comhair… - … of Physiology-Lung …, 2008 - journals.physiology.org
Hyaluronan (HA), a large glycosaminoglycan found in the ECM, has major roles in lung and
vascular biology and disease. However, its role in idiopathic pulmonary arterial …

[PDF][PDF] The relationship between inflammation and slow coronary flow: increased red cell distribution width and serum uric acid levels

N Kalay, M Aytekin, MG Kaya, K Ozbek… - … Kardiyol Dern Ars, 2011 - jag.journalagent.com
Sonuç: Bulgularımız YKA’lı hastalarda KHDG ve serum ürik asit düzeyinin anlamlı derecede
yükseldiğini göstermiştir. Bu bulgu YKA’nın patofizyolojik temelini anlamamıza yardımcı …

Nitric oxide deficiency in pulmonary hypertension: pathobiology and implications for therapy

AR Tonelli, S Haserodt, M Aytekin… - Pulmonary …, 2013 - journals.sagepub.com
Nitric oxide (NO) is a diffusible gas with diverse roles in human physiology and disease.
Significant progress in the understanding of its biological effects has taken place in recent years. …

Sensitive cardiac troponin I predicts poor outcomes in pulmonary arterial hypertension

GA Heresi, WHW Tang, M Aytekin… - European respiratory …, 2012 - Eur Respiratory Soc
Circulating cardiac troponins are markers of myocardial injury. We sought to determine
whether cardiac troponin I (cTnI), measured by a sensitive assay, is associated with disease …

A comparison of the sensitivity, specificity, and molecular weight accuracy of three different commercially available Hyaluronan ELISA-like assays

S Haserodt, M Aytekin, RA Dweik - Glycobiology, 2011 - academic.oup.com
Hyaluronan (HA) is a glycosaminoglycan found in the extracellular matrix and ranges from
several thousand to millions of daltons in size. HA has importance in various pathological …

Plasma interleukin-6 adds prognostic information in pulmonary arterial hypertension

GA Heresi, M Aytekin, JP Hammel… - European …, 2014 - Eur Respiratory Soc
Noninvasive biomarkers are needed to aid in making challenging clinical decisions in
pulmonary arterial hypertension (PAH). Several biomarkers have been described, but only the …

Pronounced transcriptional regulation of apoptotic and TNF–NF-kappa-B signaling genes during the course of thymoquinone mediated apoptosis in HeLa cells

C Sakalar, M Yuruk, T Kaya, M Aytekin, S Kuk… - Molecular and cellular …, 2013 - Springer
Thymoquinone (TQ) is the active ingredient extracted from the essential oil of Nigella sativa.
A number of studies implicated TQ as an antitumor agent. In this study, cytotoxic effects of …

[HTML][HTML] Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase

…, K Manchanda, T Ravekes, GA Heresi, M Aytekin… - JCI insight, 2018 - ncbi.nlm.nih.gov
Pulmonary arterial hypertension (PAH) remains a disease with limited therapeutic options
and dismal prognosis. Despite its etiologic heterogeneity, the underlying unifying …