Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis

…, J Choi, LJ Vuga, KO Lindell, M Klesen… - American journal of …, 2012 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology
with a variable and unpredictable course. Objectives: The aim of this study was to identify and …

Validation of a 52-gene risk profile for outcome prediction in patients with idiopathic pulmonary fibrosis: an international, multicentre, cohort study

…, N Aurelien, KO Lindell, MJ Klesen… - The Lancet …, 2017 - thelancet.com
Background The clinical course of idiopathic pulmonary fibrosis (IPF) is unpredictable.
Clinical prediction tools are not accurate enough to predict disease outcomes. Methods We …

Randomised clinical trial of an early palliative care intervention (SUPPORT) for patients with idiopathic pulmonary fibrosis (IPF) and their caregivers: protocol and key …

KO Lindell, M Nouraie, MJ Klesen… - BMJ open …, 2018 - bmjopenrespres.bmj.com
Introduction Idiopathic pulmonary fibrosis (IPF), a progressive life-limiting lung disease affects
approximately 128 000 newly diagnosed individuals in the USA annually. IPF, a disease …

Peripheral blood biomarkers predict disease progression and mortality in IPF

TJ Richards, KO Lindell, M Klesen… - A23. IDIOPATHIC …, 2010 - atsjournals.org
Methods Plasma samples were obtained from 143 IPF patients and 72 controls. Concentrations
of 95 cytokines and chemokines, matrix metalloproteinases (MMPs), and markers of …

Lessons learned when recruiting for an early Idiopathic Pulmonary Fibrosis (IPF) palliative care intervention

K Lindell, M Nouraie, S Klein, M Klesen, K Gibson… - 2018 - Eur Respiratory Soc
Despite an extensive body of literature for palliative care (PC) as standard of care in patients
with life-limiting conditions, referrals to palliative care for patients with advanced lung …

Discovery and validation of peripheral blood gene expression profiles predictive of poor outcome and disease progression in idiopathic pulmonary fibrosis

…, J DeIullis, G Yu, K Sakamoto, M Klesen… - European …, 2014 - Eur Respiratory Soc
Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease associated with
increase mortality. In this study we aim to identify and validate peripheral blood mononuclear …

[CITATION][C] Evaluating Nutritional Status In Patients With Idiopathic Pulmonary Fibrosis: A Prospective Pilot Study Using The Mini Nutritional Assessment Short Form

K Autore, T Black, M Klesen, T Richards… - A42. Interstitial Lung …, 2013 - atsjournals.org
Methods Thirty-one (31) IPF patients recruited from the Genomics and Proteomics (GAP)
study at the Simmons Center for Interstitial Lung Disease at the University of Pittsburgh were …

[CITATION][C] Self-Reported Dyspnea In Ipf Patients Related To Clinical Diagnostics And Gap Score

TR Black, M Klesen, R Bissonetter… - C42. CREATING THE …, 2013 - atsjournals.org
Methods: A total of 122 IPF patients were recruited at visit 1 and 57 remained alive and
untransplanted for longitudinal follow-up in a biomarker study at the University of Pittsburgh …

[CITATION][C] The Peripheral Blood 52 Gene Survival Signature Is Also Indicative Of Disease Progression In Patients With Idiopathic Pulmonary Fibrosis

…, G Yu, K Sakamoto, M Klesen… - D91. NOVEL …, 2014 - atsjournals.org
Rationale: outcomes by microarrays. In this study, we aimed to validate the outcome
prediction potential of this signature in a large cohort of IPF patients and to identify whether it …

[CITATION][C] Dyspnea Is A Strong Predictor Of Survival And Correlates With Genomic Markers Of Poor Idiopathic Pulmonary Fibrosis Outcomes

KO Lindell, KF Gibson, MS Klesen… - A42 …, 2014 - atsjournals.org
Pulmonary Fibrosis (IPF) patients with differences in microarray gene expression and survival.
In this study, we aimed to validate whether SOBQ score at presentation is predictive of …