Background The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial.
We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with …

A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella
pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted …

Background Infections with SARS-CoV-2 continue to cause significant morbidity and mortality.
Interleukin (IL)-1 and IL-6 blockade have been proposed as therapeutic strategies in …

Background A range of safe and effective vaccines against SARS CoV 2 are needed to
address the COVID 19 pandemic. We aimed to assess the safety and efficacy of the COVID-19 …

Background Interpretation of the evidence from randomised controlled trials (RCTs) of
remdesivir in patients treated in hospital for COVID-19 is conflicting. We aimed to assess the …

Background Rezafungin is a next-generation, once-a-week echinocandin in development
for the treatment of candidaemia and invasive candidiasis and for the prevention of invasive …

Introduction: Although β-lactams are considered to have a safe therapeutic profile, neurotoxicity
has been reported. The aim of this study was to assess the association between-lactam …

The increased prevalence of obesity presents challenges for clinicians aiming to provide
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …

Severe sepsis and septic shock can alter the pharmacokinetics of broad-spectrum β-lactams
(meropenem, ceftazidime/cefepime, and piperacillin-tazobactam), resulting in inappropriate …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (%T) during which their free serum concentration …