[HTML][HTML] Cellular immunity predominates over humoral immunity after homologous and heterologous mRNA and vector-based COVID-19 vaccine regimens in solid …

…, V Klemis, D Schub, S Schneitler, MC Reichert… - American Journal of …, 2021 - Elsevier
Knowledge on the immunogenicity of vector-based and mRNA-vaccines in solid organ
transplant recipients is limited. Therefore, SARS-CoV-2–specific T cells and antibodies were …

[PDF][PDF] LUBAC-recruited CYLD and A20 regulate gene activation and cell death by exerting opposing effects on linear ubiquitin in signaling complexes

P Draber, S Kupka, M Reichert, H Draberova, E Lafont… - Cell reports, 2015 - cell.com
Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling
complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various …

[HTML][HTML] Efficacy of budesonide orodispersible tablets as induction therapy for eosinophilic esophagitis in a randomized placebo-controlled trial

…, H Buchholz, F Lammert, M Casper, M Reichert… - Gastroenterology, 2019 - Elsevier
Background & Aims Swallowed topical-acting corticosteroids are recommended as first-line
therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized for …

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

E Lafont, P Draber, E Rieser, M Reichert, S Kupka… - Nature cell …, 2018 - nature.com
The linear-ubiquitin chain assembly complex (LUBAC) modulates signalling via various
immune receptors. In tumour necrosis factor (TNF) signalling, linear (also known as M1) …

[HTML][HTML] rs641738C> T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

…, CA Parisinos, SG Pillai, F Qayyum, MC Reichert… - Journal of …, 2021 - Elsevier
Background & Aims A common genetic variant near MBOAT7 (rs641738C>T) has been
previously associated with hepatic fat and advanced histology in NAFLD; however, these …

Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality

…, S Zewinger, S Triem, P Ege, MC Reichert… - European heart …, 2021 - academic.oup.com
Aims Inflammation plays an important role in cardiovascular disease (CVD) development.
The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of …

Heterozygous carriage of the alpha1-antitrypsin Pi* Z variant increases the risk to develop liver cirrhosis

…, M Trauner, MJ Way, A McQuillin, MC Reichert… - Gut, 2019 - gut.bmj.com
Objective Homozygous alpha1-antitrypsin (AAT) deficiency increases the risk for developing
cirrhosis, whereas the relevance of heterozygous carriage remains unclear. Hence, we …

The linear ubiquitin chain assembly complex regulates TRAIL‐induced gene activation and cell death

…, P Draber, D De Miguel, T Hartwig, M Reichert… - The EMBO …, 2017 - embopress.org
The linear ubiquitin chain assembly complex ( LUBAC ) is the only known E3 ubiquitin ligase
which catalyses the generation of linear ubiquitin linkages de novo. LUBAC is a crucial …

Liver fibrosis and metabolic alterations in adults with alpha-1-antitrypsin deficiency caused by the Pi* ZZ mutation

…, LS Moeller, M Pons, GE Dolman, MC Reichert… - Gastroenterology, 2019 - Elsevier
Background & Aims Alpha-1 antitrypsin deficiency (AATD) is among the most common genetic
disorders. Severe AATD is caused by a homozygous mutation in the SERPINA1 gene that …

Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms

…, JW Harrison, S Buch, C Lange, MC Reichert… - Gut, 2019 - gut.bmj.com
Objective Diverticular disease is a common complex disorder characterised by mucosal
outpouchings of the colonic wall that manifests through complications such as diverticulitis, …