[HTML][HTML] Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD

…, M McCormick, J Woods, R May, MA Sleeman… - Chest, 2010 - Elsevier
Background Asthma and COPD are characterized by airway dysfunction and inflammation.
Neutrophilic airway inflammation is a common feature of COPD and is recognized in asthma, …

Identification of a new fibroblast growth factor receptor, FGFR5

M Sleeman, J Fraser, M McDonald, S Yuan, D White… - Gene, 2001 - Elsevier
A novel fibroblast growth factor receptor (FGFR), designated FGFR5, was identified from an
EST database of a murine lymph node stromal cell cDNA library. The EST has approximately …

[HTML][HTML] The epithelium in idiopathic pulmonary fibrosis: breaking the barrier

A Camelo, MA Sleeman, DL Clarke - Frontiers in pharmacology, 2014 - frontiersin.org
Idiopathic pulmonary fibrosis is a progressive disease of unknown etiology characterized by
a dysregulated wound healing response that leads to fatal accumulation of fibroblasts and …

[HTML][HTML] Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

…, DR Higazi, DJ Corkill, RD May, MA Sleeman… - Nature …, 2015 - nature.com
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin
(IL)-33 to elicit a rapid immune response. However, little is known about the regulation …

Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation

…, N Stahl, GD Yancopoulos, AJ Murphy, MA Sleeman… - Allergy, 2020 - Wiley Online Library
Background Dupilumab, a fully human monoclonal antibody that binds IL‐4Rα and inhibits
signaling of both IL‐4 and IL‐13, has shown efficacy across multiple diseases with underlying …

Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses

…, C Cortez, I Lowy, AJ Murphy, MA Sleeman… - Science …, 2021 - science.org
Although radiotherapy has been used for over a century to locally control tumor growth,
alone it rarely induces an abscopal response or systemic antitumor immunity capable of …

[HTML][HTML] Cloning and biological activity of epigen, a novel member of the epidermal growth factor superfamily

…, JG Murison, RL Prestidge, MA Sleeman… - Journal of Biological …, 2001 - ASBMB
High throughput sequencing of a mouse keratinocyte library was used to identify an expressed
sequence tag with homology to the epidermal growth factor (EGF) family of growth factors…

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis

…, I Szombati, E Esfandiari, MA Sleeman… - Annals of the …, 2013 - ard.bmj.com
Objectives Mavrilimumab, a human monoclonal antibody targeting the alpha subunit of the
granulocyte-macrophage colony-stimulating factor receptor, was evaluated in a phase 2 …

IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells

…, RA Stewart, C Overed-Sayer, MA Sleeman… - Blood …, 2017 - ashpublications.org
Innate lymphoid cells (ILCs) represent a distinct branch of the lymphoid lineage composed
of 3 major subpopulations: ILC1, ILC2, and ILC3. ILCs are mainly described as tissue-…

Moving toward endotypes in atopic dermatitis: identification of patient clusters based on serum biomarker analysis

…, BR Sellman, T Mustelin, MA Sleeman… - Journal of Allergy and …, 2017 - Elsevier
Background Atopic dermatitis (AD) is a complex, chronic, inflammatory skin disease with a
diverse clinical presentation. However, it is unclear whether this diversity exists at a biological …