An evaluation of orthogonal signal correction applied to calibration transfer of near infrared spectra

J Sjöblom, O Svensson, M Josefson, H Kullberg… - Chemometrics and …, 1998 - Elsevier
Orthogonal signal correction (OSC) is a technique for pre-processing of, for example, NIR-spectra
before they are subjected to a multivariate calibration. With OSC the X-matrix is …

Quantitative analysis of film coating in a fluidized bed process by in-line NIR spectrometry and multivariate batch calibration

…, J Gottfries, MO Johansson, M Josefson… - Analytical …, 2000 - ACS Publications
A method is described which enables real-time analysis of film coating on pharmaceutical
pellets during an industrial manufacturing process. Measurements were conducted on the …

Internal standard in surface-enhanced Raman spectroscopy

…, J Engelbrektsson, C Eliasson, M Josefson… - Analytical …, 2004 - ACS Publications
A method is presented for the use of SAM layers as internal standards for calibration in
surface-enhanced Raman spectroscopy. Three cyano-containing compounds were attached to …

A quality by design approach to investigate the effect of mannitol and dicalcium phosphate qualities on roll compaction

…, M Fransson, O Svensson, M Josefson… - International journal of …, 2013 - Elsevier
Roll compaction is a continuous process for solid dosage form manufacturing increasingly
popular within pharmaceutical industry. Although roll compaction has become an established …

Reaction monitoring using Raman spectroscopy and chemometrics

O Svensson, M Josefson, FW Langkilde - Chemometrics and intelligent …, 1999 - Elsevier
The synthesis and hydrolysis of ethyl acetate was monitored with a Raman spectrometer
equipped with a 785-nm laser, confocal optics, an optical fiber, a holographic transmission …

Roll compaction process modeling: Transfer between equipment and impact of process parameters

…, P Tajarobi, H Wikström, G Haeffler, M Josefson… - International journal of …, 2015 - Elsevier
In this study, the roll compaction of an intermediate drug load formulation was performed
using horizontally and vertically force fed roll compactors. The horizontally fed roll compactor …

Transfer of NIR calibrations for pharmaceutical formulations between different instruments

EL Bergman, H Brage, M Josefson, O Svensson… - … of pharmaceutical and …, 2006 - Elsevier
In order to evaluate how well existing techniques for transferring NIR calibrations perform
for solid pharmaceutical formulations, a study on four assays of active ingredients was …

Time-resolved NIR/Vis spectroscopy for analysis of solids: Pharmaceutical tablets

J Johansson, S Folestad, M Josefson, A Sparén… - Applied …, 2002 - opg.optica.org
Time-resolved spectroscopy in the visible and near-infrared (NIR) regions was used in a
feasibility study for analysis of solid pharmaceuticals. The objective of the experiments was to …

Design space estimation of the roller compaction process

N Souihi, M Josefson, P Tajarobi… - Industrial & …, 2013 - ACS Publications
Roller compaction (RC) is a continuous process for solid dosage form manufacturing within
the pharmaceutical industry achieving similar goals as wet granulation while avoiding liquid …

TOF-SIMS analysis of exhaled particles from patients with asthma and healthy controls

AC Almstrand, M Josefson, A Bredberg… - European …, 2012 - Eur Respiratory Soc
Particles in exhaled air (PEx) may reflect the composition of respiratory tract lining fluid (RTLF);
thus, there is a need to assess their potential as sources of biomarkers for respiratory …