Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-β in human fibrotic lung fibroblasts and promotes …
…, H Booth, GJ Laurent, SL Hart, ML Foster… - The American journal of …, 2001 - Elsevier
Prostaglandin E 2 (PGE 2 ) inhibits fibroblast proliferation and collagen production. Its synthesis
by fibroblasts is induced by profibrotic mediators including transforming growth factor (…
by fibroblasts is induced by profibrotic mediators including transforming growth factor (…
[HTML][HTML] Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized
…, RA Maciewicz, P Newham, M Foster… - Arthritis research & …, 2009 - Springer
Introduction Although the presence of bone marrow lesions (BMLs) on magnetic resonance
images is strongly associated with osteoarthritis progression and pain, the underlying …
images is strongly associated with osteoarthritis progression and pain, the underlying …
[HTML][HTML] Isolation and characterisation of potential respiratory syncytial virus receptor (s) on epithelial cells
R Malhotra, M Ward, H Bright, R Priest, MR Foster… - Microbes and …, 2003 - Elsevier
Respiratory syncytial virus (RSV) infection causes severe lower respiratory diseases in
infancy, early childhood and the elderly. RSV infections respond poorly to current therapies. …
infancy, early childhood and the elderly. RSV infections respond poorly to current therapies. …
Human peritoneal adhesions are highly cellular, innervated, and vascularized
…, A Omer, P Boulos, ML Foster… - The Journal of …, 2000 - Wiley Online Library
Peritoneal adhesions are a major complication of healing following surgery or infection and
can lead to conditions such as intestinal obstruction, infertility, and chronic pain. Mature …
can lead to conditions such as intestinal obstruction, infertility, and chronic pain. Mature …
[HTML][HTML] IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice
…, CCJ Zavitz, A Kelly, KN Lambert, S Piper, ML Foster… - PloS one, 2011 - journals.plos.org
Background Cigarette smoking is the main risk factor for the development of chronic obstructive
pulmonary disease (COPD), a major cause of morbidity and mortality worldwide. Despite …
pulmonary disease (COPD), a major cause of morbidity and mortality worldwide. Despite …
Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity
…, TJ Brown, SE Webber, ML Foster - The Journal of …, 2001 - journals.aai.org
Glucocorticoids (GCs) are the mainstay of asthma therapy; however, major side effects limit
their therapeutic use. GCs influence the expression of genes either by transactivation or …
their therapeutic use. GCs influence the expression of genes either by transactivation or …
Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E2 production
…, GJ Laurent, SL Hart, ML Foster… - The American journal of …, 2004 - Elsevier
Levels of prostaglandin E 2 (PGE 2 ), a potent inhibitor of fibroblast function, are decreased
in the lungs of patients with pulmonary fibrosis, which has been shown to be because of …
in the lungs of patients with pulmonary fibrosis, which has been shown to be because of …
Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats
SE Mutsaers, ML Foster, RC Chambers… - American journal of …, 1998 - atsjournals.org
Endothelin-1 (Et-1) has been implicated in the pathogenesis of pulmonary fibrosis with increased
levels in the lung tissue of patients with pulmonary fibrosis and profibrotic effects in vitro…
levels in the lung tissue of patients with pulmonary fibrosis and profibrotic effects in vitro…
Tissue‐specific stem cell differentiation in an in vitro airway model
…, C Job, H Marshall, V Oreffo, M Foster… - Macromolecular …, 2011 - Wiley Online Library
The respiratory tract is the primary site of exposure to airborne compounds, with the bronchial
epithelium providing one of the first lines of defence. A growing need exists for an accurate …
epithelium providing one of the first lines of defence. A growing need exists for an accurate …
[HTML][HTML] CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans
JD Campbell, Y Cho, ML Foster… - The Journal of …, 2009 - Am Soc Clin Investig
CpG-containing immunostimulatory DNA sequences (ISS), which signal through TLR9, are
being developed as a therapy for allergic indications and have proven to be safe and well …
being developed as a therapy for allergic indications and have proven to be safe and well …