Prevention of pulmonary hypoplasia and pulmonary vascular remodeling by antenatal simvastatin treatment in nitrofen-induced congenital diaphragmatic hernia

M Makanga, H Maruyama… - … of Physiology-Lung …, 2015 - journals.physiology.org
Congenital diaphragmatic hernia (CDH) has a high mortality rate mainly due to lung hypoplasia
and persistent pulmonary hypertension of the newborn (PPHN). Simvastatin has been …

Downregulated bone morphogenetic protein signaling in nitrofen-induced congenital diaphragmatic hernia

M Makanga, C Dewachter, H Maruyama… - Pediatric surgery …, 2013 - Springer
Purpose Bone morphogenetic proteins (BMP) have been shown to play crucial roles in not
only lung and heart development, but also in the pathogenesis of pulmonary vascular …

[HTML][HTML] Pulmonary vasoreactivity in spontaneously hypertensive rats-Effects of endothelin-1 and leptin

S Gomart, C Damoiseaux, P Jespers, M Makanga… - Respiratory …, 2014 - Springer
Background Systemic hypertension may be associated with an increased pulmonary vascular
resistance, which we hypothesized could be, at least in part, mediated by increased leptin. …

Antenatal sildenafil-simvastatin combination attenuates pulmonary hypoplasia and hypertension in nitrofen-induced congenital diaphragmatic hernia

C Dewachter, M Makanga, H Maruyama, E Hupkens… - 2016 - Eur Respiratory Soc
Background: Congenital diaphragmatic hernia (CDH) has a high mortality rate mainly due
to lung hypoplasia and persistent pulmonary hypertension of the newborn (PPHN). We …

Downregulated BMPR2 signaling pathway in nitrofen-induced pulmonary hypoplasia

M Makanga, C Dewachter, B Rondelet, R Naeije… - 2011 - Eur Respiratory Soc
Background: Despite remarkable progress in resuscitation and intensive care, morbidity and
mortality in congenital diaphragmatic hernia (CDH) remain high due to severe pulmonary …

Bone morphogenetic protein signaling in experimental nitrofen-induced congenital diaphragmatic hernia

M Makanga, C Dewachter, A Vuckovic, B Rondelet… - 2012 - Eur Respiratory Soc
Congenital diaphragmatic hernia (CDH) is a life-threatening cause of lung hypoplasia and
persistent pulmonary hypertension of the newborn. As bone morphogenetic proteins (BMP) …

HIV/AIDS among surgical patients in Butare University Teaching Hospital

M Makanga, R Kabera, A Nzayisenga… - East and Central African …, 2007 - ajol.info
Background: Despite the increasing number of patients with the human immunodeficiency
virus (HIV) infection particularly in Sub-Saharan Africa, surgical experience with these …

Childhood bone and soft tissue tumours: A review of 43 treated at two University Teaching Hospitals in Rwanda (CHUB and CHUK) in RWANDA

M Makanga, JP Majyambere, I Kakande - East and Central African Journal …, 2008 - ajol.info
Back ground: Cancer represents one of the major causes of death in the world estimated at
1 out of 10 deaths. Globally, 160,000 children are diagnosed to have cancer each year. In …

Anorectal malformations at University teaching hospital of butare in Rwanda: a review of 46 operative cases

M Makanga, F Ntirenganya, I Kakande - East and Central African Journal of …, 2007 - ajol.info
Background: Anorectal malformations (ARM) are comprised of a wide spectrum of disease
that involves congenital anomalies of the anus and rectum, as well as the urinary and genital …

[PDF][PDF] A pragmatic analysis of figurative language used in HIV/AIDS discourse in Kenia: a case study of english and Kiswahili messages

L Magonya - 2012 - Citeseer
This research investigates whether Kenyans from 42 mutually intelligible communities
homogeneously comprehend AIDS posters. In this regard, the five research objectives are:(1) to …