T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance

…, A Foryst-Ludwig, M Clemenz, M Wabitsch… - … , and vascular biology, 2008 - Am Heart Assoc
Background— Adipose tissue inflammation may play a critical role in the pathogenesis of
insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue …

Overweight and obesity in European children: definition and diagnostic procedures, risk factors and consequences for later health outcome

M Wabitsch - European journal of pediatrics, 2000 - Springer
In this article, information on the definition of obesity in childhood and adolescence, its
differential diagnosis and its adverse health effects is provided. This information can be …

Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium.

H Hauner, G Entenmann, M Wabitsch… - The Journal of …, 1989 - Am Soc Clin Investig
Stromal-vascular cells obtained from adult human subcutaneous adipose tissue were cultured
in a chemically defined serum-free medium. In the presence of 0.2 nM triiodothyronine …

[PDF][PDF] The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

…, WB van den Berg, N van Rooijen, M Wabitsch… - Cell metabolism, 2010 - cell.com
Obesity-induced inflammation originating from expanding adipose tissue interferes with
insulin sensitivity. Important metabolic effects have been recently attributed to IL-1β and IL-18, …

Insulin and cortisol promote leptin production in cultured human fat cells

M Wabitsch, P Bo Jensen, WF Blum… - Diabetes, 1996 - Am Diabetes Assoc
The aim of this study was to investigate the regulation of leptin expression and production in
cultured human adipocytes using the model of in vitro differentiated human adipocytes. …

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

…, L Doyle, B Phipson, GK Smyth, M Wabitsch… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Insulin resistance and other features of the metabolic syndrome have been
causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We …

Protocol for effective differentiation of 3T3-L1 cells to adipocytes

K Zebisch, V Voigt, M Wabitsch, M Brandsch - Analytical biochemistry, 2012 - Elsevier
In this note, we present a detailed procedure for highly effective and reproducible 3T3-L1
cell differentiation. Due to their potential to differentiate from fibroblasts to adipocytes, 3T3-L1 …

Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation

M Wabitsch, RE Brenner, I Melzner, M Braun… - International journal of …, 2001 - nature.com
OBJECTIVE: To develop and to characterize a human preadipocyte cell strain with high
capacity for adipose differentiation serving as a model for studying human adipocyte …

Type 2 diabetes mellitus in children and adolescents

T Reinehr, M Wabitsch - Prevention of type 2 diabetes, 2005 - Wiley Online Library
Until very recently, Type 2 diabetes has been thought to be a rare occurrence in children
and adolescents. However, in the mid-1990s, investigators began to observe an increasing …

Contribution of androgens to the gender difference in leptin production in obese children and adolescents.

M Wabitsch, WF Blum, R Muche… - The Journal of …, 1997 - Am Soc Clin Investig
Recent studies demonstrated significantly higher serum leptin concentrations in females as
compared with males, even after correction for differences in body fat mass. The aim of our …