Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
A Stančáková, M Javorský, T Kuulasmaa… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE We evaluated insulin sensitivity and insulin secretion across the entire range of
fasting (FPG) and 2-h plasma glucose (PG), and we investigated the differences in insulin …
fasting (FPG) and 2-h plasma glucose (PG), and we investigated the differences in insulin …
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
…, DM Rotroff, M Out, KA Jablonski, L Chen, M Javorský… - Nature …, 2016 - nature.com
Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its
mechanism of action remains unclear 1 . Here the Metformin Genetics (MetGen) Consortium …
mechanism of action remains unclear 1 . Here the Metformin Genetics (MetGen) Consortium …
Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study
R Tkacova, WT McNicholas, M Javorsky… - European …, 2014 - Eur Respiratory Soc
Systemic hypertension is associated with obstructive sleep apnoea syndrome (OSAS) but
the pathophysiological mechanisms are incompletely understood. A collaborative European …
the pathophysiological mechanisms are incompletely understood. A collaborative European …
KCNJ11 gene E23K variant and therapeutic response to sulfonylureas
M Javorsky, L Klimcakova, Z Schroner, J Zidzik… - European journal of …, 2012 - Elsevier
AIMS: Potassium inwardly rectifier 6.2 subunit (Kir6.2) of the ATP-sensitive potassium (K
ATP ) channel encoded by KCNJ11 gene is a therapeutical target for sulfonylureas. KCNJ11 …
ATP ) channel encoded by KCNJ11 gene is a therapeutical target for sulfonylureas. KCNJ11 …
Variants in pharmacokinetic transporters and glycemic response to metformin: a Metgen meta‐analysis
…, CE de Keyser, M Javorský… - Clinical …, 2017 - Wiley Online Library
Therapeutic response to metformin, a first‐line drug for type 2 diabetes (T2D), is highly
variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have …
variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have …
Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities
J Figurová, I Dravecká, M Javorský, J Petríková… - Wiener klinische …, 2016 - Springer
Objective To investigate prevalence of vitamin D deficiency and its relation to clinical,
anthropometrical, and biochemical findings in polycystic ovary syndrome (PCOS) and controls. …
anthropometrical, and biochemical findings in polycystic ovary syndrome (PCOS) and controls. …
Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to …
…, S Grinberga, J Židzik, M Javorský… - European Journal of …, 2016 - academic.oup.com
Objective(s) High variability in clinical response to metformin is often observed in type 2
diabetes (T2D) patients, and it highlights the need for identification of genetic components …
diabetes (T2D) patients, and it highlights the need for identification of genetic components …
Relationship between osteoporosis and adipose tissue leptin and osteoprotegerin in patients with chronic obstructive pulmonary disease
…, B Ukropcova, P Joppa, T Kurdiova, M Javorsky… - Bone, 2011 - Elsevier
INTRODUCTION: The role of fat–bone interactions in the pathogenesis of osteoporosis in
chronic obstructive pulmonary disease (COPD) is poorly understood. Our aim was to …
chronic obstructive pulmonary disease (COPD) is poorly understood. Our aim was to …
Genetic variants associated with glycemic response to treatment with dipeptidylpeptidase 4 inhibitors
A Űrgeová, M Javorský, L Klimčáková, J Židzik… - …, 2020 - Future Medicine
Aim: We examined associations of eight SNPs in/near seven candidate genes with glycemic
response to 6 month treatment with DPP4 inhibitors. Patients & methods: 206 patients with …
response to 6 month treatment with DPP4 inhibitors. Patients & methods: 206 patients with …
[HTML][HTML] Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide
M Javorský, E Babjaková, L Klimčáková… - International Journal of …, 2013 - hindawi.com
Previous studies showed associations between variants in TCF7L2 gene and the therapeutic
response to sulfonylureas. All sulfonylureas stimulate insulin secretion by the closure of …
response to sulfonylureas. All sulfonylureas stimulate insulin secretion by the closure of …