Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention

M Braddock, A Quinn - Nature reviews Drug discovery, 2004 - nature.com
The cytokine interleukin-1 (IL-1) is important in many human diseases, and drives a wide
range of inflammatory responses in a number of cell types. Biological agents that target IL-1 …

HIV expression strategies: ribosomal frameshifting is directed by a short sequence in both mammalian and yeast systems

W Wilson, M Braddock, SE Adams, PD Rathjen… - Cell, 1988 - cell.com
The pal gene of the human immunodeficiency virus (HIV-l) is expressed as a gag: po/fusion,
arising from a ribosomal frameshift that brings the overlapping, out-of-phase gag and pal …

Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen …

…, C Campbell, V Sukhatme, M Braddock - The Journal of …, 1998 - Am Soc Clin Investig
The primary response transcription factor, early growth response-1 (Egr-1), is rapidly activated
by a variety of extracellular stimuli. Egr-1 binds to a sequence found in the promoters of …

Born again bone: tissue engineering for bone repair

M Braddock, P Houston, C Campbell… - Physiology, 2001 - journals.physiology.org
Destruction of bone tissue due to disease and inefficient bone healing after traumatic injury
may be addressed by tissue engineering techniques. Growth factor, cytokine protein, and …

Safety and efficacy of an oral inhibitor of the purinergic receptor P2X7 in adult patients with moderately to severely active Crohn's disease: a randomized placebo …

…, S Vermeire, H Vogelsang, M Braddock… - Inflammatory bowel …, 2015 - academic.oup.com
Background AZD9056 is a selective orally active inhibitor of the purinergic receptor P2X 7 ,
which is a key player in the generation and secretion of several proinflammatory cytokines …

Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS) …

…, S Siddiqui, M Wang, M Braddock… - The Lancet …, 2018 - thelancet.com
Background The role of interleukin 13 in airway inflammation and remodelling in asthma is
unclear. Tralokinumab is a human monoclonal antibody that neutralises interleukin 13. We …

P2X7 receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases

…, P Pelegrin, AD Clifton, M Braddock… - The Journal of …, 2010 - journals.aai.org
The ATP-gated P2X 7 receptor (P2X 7 R) is a promising therapeutic target in chronic inflammatory
diseases with highly specific antagonists currently under clinical trials for rheumatoid …

Fluid shear stress modulation of gene expression in endothelial cells

M Braddock, JL Schwachtgen, P Houston… - …, 1998 - journals.physiology.org
The vascular endothelium, lining the blood vessel wall, is constantly exposed to wall shear
stresses generated by flowing blood. Gene regulation, critical for endothelial cell function, …

Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists

A Baxter, J Bent, K Bowers, M Braddock… - Bioorganic & medicinal …, 2003 - Elsevier
… Author links open overlay panel Andrew Baxter , Janice Bent , Keith Bowers , Martin
Braddock , Steve Brough , Malbinder Fagura , Mandy Lawson , Tom McInally , Mike …

[HTML][HTML] Systematic review with network meta-analysis: antidiabetic medication and risk of hepatocellular carcinoma

…, T Liu, JN Zheng, Z Cheng, TT Zou, M Braddock… - Scientific reports, 2016 - nature.com
Antidiabetic medication may modify the incidence of hepatocellular carcinoma (HCC). We
aimed to compare the use of different antidiabetic strategies and the incidence of HCC. …