[HTML][HTML] Exposure to environmental microorganisms and childhood asthma

MJ Ege, M Mayer, AC Normand… - … England Journal of …, 2011 - Mass Medical Soc
Background Children who grow up in environments that afford them a wide range of microbial
exposures, such as traditional farms, are protected from childhood asthma and atopy. In …

The asthma epidemic

W Eder, MJ Ege, E von Mutius - New England Journal of …, 2006 - Mass Medical Soc
This review surveys the data on the increase in the prevalence of asthma in recent decades
and finds evidence of a plateau in many Western countries. The authors examine the …

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

…, MJ Ege - Nature medicine, 2020 - nature.com
Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …

Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children

MJ Ege, C Bieli, R Frei, RT van Strien, J Riedler… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: There is increasing evidence that environmental exposures determining
childhood illnesses operate early in life. Prenatal exposure to a farming environment through …

Not all farming environments protect against the development of asthma and wheeze in children

MJ Ege, R Frei, C Bieli, D Schram-Bijkerk… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: In recent years, studies have shown a protective effect of being raised in a
farm environment on the development of hay fever and atopic sensitization. Inconsistent data …

The hygiene hypothesis in the age of the microbiome

MJ Ege - Annals of the American Thoracic Society, 2017 - atsjournals.org
The original version of the hygiene hypothesis suggested that infections transmitted early in
life by “unhygienic contact” prevented allergies. Examples were endemic fecal–oral …

Microbes and asthma: opportunities for intervention

HH Smits, PS Hiemstra, CP Da Costa, M Ege… - Journal of Allergy and …, 2016 - Elsevier
The worldwide incidence and prevalence of asthma continues to increase. Asthma is now
understood as an umbrella term for different phenotypes or endotypes, which arise through …

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

…, MA Willart, K Vergote, D Gras, K Deswarte, MJ Ege… - Science, 2015 - science.org
Growing up on a dairy farm protects children from allergy, hay fever, and asthma. A mechanism
linking exposure to this endotoxin (bacterial lipopolysaccharide)–rich environment with …

Farm-like indoor microbiota in non-farm homes protects children from asthma development

…, G Loss, B Jayaprakash, M Depner, MJ Ege… - Nature medicine, 2019 - nature.com
Asthma prevalence has increased in epidemic proportions with urbanization, but growing
up on traditional farms offers protection even today 1 . The asthma-protective effect of farms …

Clinical and epidemiologic phenotypes of childhood asthma

…, E Von Mutius, MJ Ege… - American journal of …, 2014 - atsjournals.org
Rationale: Clinical and epidemiologic approaches have identified two distinct sets of
classifications for asthma and wheeze phenotypes. Objectives: To compare epidemiologic …