Transforming growth factor β (TGF‐β), a key mediator of fibrotic responses, is increased in
asthma and drives airway remodeling by inducing expression of extracellular matrix (ECM) …

Airway remodelling, characterised by increased airway smooth muscle (ASM) mass, subepithelial
fibrosis, goblet cell hyperplasia and mucus gland hypertrophy, is a feature of chronic …

Chronic inflammatory airway diseases like asthma and chronic obstructive pulmonary
disease (COPD) are characterized by airway remodeling with altered extracellular matrix (ECM) …

Dysfunctional regulation of airway smooth muscle tone is a feature of obstructive airway
diseases such as asthma and chronic obstructive pulmonary disease. Airway smooth muscle …

Cigarette smoke-induced release of pro-inflammatory cytokines including interleukin-8 (IL-8)
from inflammatory as well as structural cells in the airways, including airway smooth muscle …

Airway inflammation and remodeling are major features of chronic obstructive pulmonary
disease (COPD), whereas pulmonary hypertension is a common comorbidity associated with a …

Background Chronic lung diseases such as asthma, COPD and pulmonary fibrosis are
characterized by abnormal extracellular matrix ( ECM ) turnover. TGF ‐β is a key mediator …

COPD is a progressive chronic lung disease characterized by pulmonary inflammation. Several
recent studies indicate aberrant expression of WNT ligands and Frizzled receptors in the …

Background: COPD is a progressive lung disease characterized by emphysema and enhanced
bronchoconstriction. Current treatments focused on bronchodilation can delay disease …

WNT-5A, a key player in embryonic development and post-natal homeostasis, has been
associated with a myriad of pathological conditions including malignant, fibroproliferative and …