We conducted a placebo-controlled, double-blind, randomized study to evaluate the
microbiological efficacy and safety of inhaled tobramycin for treatment of patients with …

Objectives: The purpose of this study was to determine the tissue and corresponding serum
concentration of tigecycline at selected time points in gall bladder, bile, colon, bone, synovial …

Background Gefapixant is a P2X3 receptor antagonist that has shown promise for the treatment
of refractory and unexplained chronic cough. The aim of this study was to evaluate the …

In addition to their well-known antimicrobial activity, macrolides possess immunomodulatory
properties that may confer beneficial effects to patients with respiratory diseases associated …

… performed in each subject at 4 h, 12 h, or 24 h after the last administered dose of antibiotic.
… The concentrations of ciprofloxacin at 4 h and 12 h in ELF were 1.9 ± 0.9 μμg/mL and 0.4 ± …

The need for a less invasive procedure than surgical lung volume reduction that can produce
consistent improvements with reduced morbidity remains a medical goal in patients with …

The steady-state concentrations of clarithromycin and azithromycin in plasma were compared
with concomitant concentrations in epithelial lining fluid (ELF) and alveolar macrophages (…

Objectives Appropriate antibiotic exposure at the site of infection is important for clinically
effective therapy. This study compared the epithelial lining fluid (ELF) penetration of ceftolozane…

The steady-state concentrations of omadacycline and tigecycline in the plasma, epithelial
lining fluid (ELF), and alveolar cells (AC) of 58 healthy adult subjects were obtained. Subjects …

The steady-state concentrations of meropenem and the β-lactamase inhibitor RPX7009 in
plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations were …