To circumvent time-consuming clinical trials, testing whether existing drugs are effective
inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this path …

The amygdala is a core component of neural circuits that mediate processing of emotional,
particularly anxiety and fear-related stimuli across species. In addition, the nuclear complex …

To investigate interrelations of human obligate airway pathogens, such as Bordetella pertussis,
and their hosts test systems with high in vitro/in vivo correlation are of urgent need. Using …

Three-dimensional respiratory tissue models have been generated using, for example, human
primary airway epithelial cells (hAEC) or respective cell lines. To investigate ciliopathies, …

Oxidoreductases are major enzymes of xenobiotic metabolism. Consequently, they are essential
in the chemoprotection of the human body. Many xenobiotic metabolism enzymes have …

In vitro test systems gain increasing importance in preclinical studies to increase the predictivity
and reduce animal testing. Of special interest herein are barrier tissues that guard into …

Background Anthocyanin-containing plant extracts and carotenoids, such as astaxanthin,
have been well-known for their antiviral and anti-inflammatory activity, respectively. We …

Transmission of measles virus (MV) from dendritic to airway epithelial cells is considered as
crucial to viral spread late in infection. Therefore, pathways and effectors governing this …

Different bioengineering techniques have been applied repeatedly for the reconstruction of
extensive airway defects in the last few years. While short-term surgical success is evident, …

Aspirin, with its active compound acetylsalicylic acid (ASA), shows antiviral activity against
rhino- and influenza viruses at high concentrations. We sought to investigate whether ASA …