User profiles for Maria Rosa Bono

Maria Rosa Bono

Profesor titular Universidad de Chile
Verified email at uchile.cl
Cited by 5742

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

JR Mora, MR Bono, N Manjunath, W Weninger… - Nature, 2003 - nature.com
Whereas naive T cells migrate only to secondary lymphoid organs 1 , 2 , activation by
antigen confers to T cells the ability to home to non-lymphoid sites 3 , 4 . Activated effector/memory …

[HTML][HTML] CD73 and CD39 ectonucleotidases in T cell differentiation: beyond immunosuppression

MR Bono, D Fernández, F Flores-Santibáñez… - FEBS letters, 2015 - Elsevier
Extracellular ATP is a danger signal released by dying and damaged cells, and it functions
as an immunostimulatory signal that promotes inflammation. However, extracellular …

Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines

C Hetz, MR Bono, LF Barros… - Proceedings of the …, 2002 - National Acad Sciences
The cytotoxic effect of microcin E492, a low-molecular-mass channel-forming bacteriocin (7,887
Da) produced by a strain of Klebsiella pneumoniae, was characterized in HeLa cells. At …

Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain

…, F Vascotto, J Boulanger, G Raposo, MR Bono… - Science, 2008 - science.org
Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present
to T cells. This requires two processes, antigen processing and cell motility, originally thought …

Towards autotrophic tissue engineering: photosynthetic gene therapy for regeneration

…, C Schwarz, HG Machens, M Heikenwalder, MR Bono… - Biomaterials, 2016 - Elsevier
The use of artificial tissues in regenerative medicine is limited due to hypoxia. As a strategy
to overcome this drawback, we have shown that photosynthetic biomaterials can produce …

[HTML][HTML] Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of …

…, V Gallardo, B Van Zundert, MR Bono… - Journal of Biological …, 2007 - ASBMB
Cellular glutathione levels may exceed vitamin C levels by 10-fold, generating the question
about the real antioxidant role that low intracellular concentrations of vitamin C can play in …

[HTML][HTML] Retinoic acid as a modulator of T cell immunity

MR Bono, G Tejon, F Flores-Santibañez, D Fernandez… - Nutrients, 2016 - mdpi.com
Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol
and retinoic acid, is an essential nutrient needed in a wide array of aspects including the …

[HTML][HTML] Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation

…, P Falcón, S Matus, I Alfaro, MR Bono… - Journal of …, 2019 - Springer
Background Neuroinflammation constitutes a pathogenic process leading to neurodegeneration
in several disorders, including Alzheimer’s disease, Parkinson’s disease (PD) and …

MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells

…, H Kagechika, R Blomhoff, M Rosemblatt, MR Bono… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans
retinoic acid (RA), which is required to induce lymphocytes to localize to the …

[HTML][HTML] The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs

…, V Manríquez, P Reyes, R Pacheco, MR Bono… - Journal of …, 2016 - Elsevier
As it has been established that demethylation of lysine 27 of histone H3 by the lysine-specific
demethylase JMJD3 increases immune responses and thus elicits inflammation, we …