Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

SM Cloonan, K Glass, ME Laucho-Contreras… - Nature medicine, 2016 - nature.com
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic
determinants. We have previously identified iron-responsive element–binding protein 2 (…

Protective role for club cell secretory protein-16 (CC16) in the development of COPD

ME Laucho-Contreras, F Polverino… - European …, 2015 - Eur Respiratory Soc
Club cell secretory protein-16 (CC16) is the major secreted product of airway club cells, but
its role in the pathogenesis of chronic obstructive pulmonary disease (COPD) is unclear. We …

A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin

…, Y Sun, J Yu, ME Laucho-Contreras… - American journal of …, 2016 - atsjournals.org
Rationale: A genetic locus within the FAM13A gene has been consistently associated with
chronic obstructive pulmonary disease (COPD) in genome-wide association studies. However…

B cell–activating factor. an orchestrator of lymphoid follicles in severe chronic obstructive pulmonary disease

…, BG Cosio, J Pons, M Laucho-Contreras… - American journal of …, 2015 - atsjournals.org
Rationale: Patients with chronic obstructive pulmonary disease (COPD) have increased
pulmonary lymphoid follicle (LF) counts. B cell–activating factor of tumor necrosis factor family (…

Club cell protein 16 (CC16) augmentation: a potential disease-modifying approach for chronic obstructive pulmonary disease (COPD)

ME Laucho-Contreras, F Polverino… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Club cell protein 16 (CC16) is the most abundant protein in bronchoalveolar
lavage fluid. CC16 has anti-inflammatory properties in smoke-exposed lungs, and chronic …

A pilot study linking endothelial injury in lungs and kidneys in chronic obstructive pulmonary disease

F Polverino, ME Laucho-Contreras… - American journal of …, 2017 - atsjournals.org
Rationale: Patients with chronic obstructive pulmonary disease (COPD) frequently have
albuminuria (indicative of renal endothelial cell injury) associated with hypoxemia. Objectives: …

ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung …

…, F Polverino, ME Laucho-Contreras… - The Journal of …, 2014 - journals.aai.org
A disintegrin and a metalloproteinase domain (ADAM) 9 is known to be expressed by monocytes
and macrophages. In this study, we report that ADAM9 is also a product of human and …

Hhip haploinsufficiency sensitizes mice to age-related emphysema

…, K Gupta, ME Laucho-Contreras… - Proceedings of the …, 2016 - National Acad Sciences
Genetic variants in Hedgehog interacting protein (HHIP) have consistently been associated
with the susceptibility to develop chronic obstructive pulmonary disease and pulmonary …

Folliculin regulates cell–cell adhesion, AMPK, and mTORC1 in a cell‐type‐specific manner in lung‐derived cells

…, C Li, A Hergrueter, M Laucho Contreras… - Physiological …, 2014 - Wiley Online Library
Germline loss‐of‐function BHD mutations cause cystic lung disease and hereditary
pneumothorax, yet little is known about the impact of BHD mutations in the lung. Folliculin (FLCN), …

Early diagnosis of COPD: myth or a true perspective

ME Laucho-Contreras… - European Respiratory …, 2020 - Eur Respiratory Soc
The early stages of COPD have recently become a hot topic as many new risk factors have
been proposed, but substantial knowledge gaps remain in explaining the natural history of …