Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses
…, N Poulos, K Samitas, M Kapasa… - Proceedings of the …, 2017 - National Acad Sciences
Type 1 regulatory T (Tr1) cells play a pivotal role in restraining human T-cell responses
toward environmental allergens and protecting against allergic diseases. Still, the precise …
toward environmental allergens and protecting against allergic diseases. Still, the precise …
Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α–dependent pathways
…, A Manousopoulou, M Kapasa… - Proceedings of the …, 2020 - National Acad Sciences
In multiple sclerosis (MS), Th17 cells are critical drivers of autoimmune central nervous
system (CNS) inflammation and demyelination. Th17 cells exhibit functional heterogeneity …
system (CNS) inflammation and demyelination. Th17 cells exhibit functional heterogeneity …
The histone variant macroH2A blocks cellular reprogramming by inhibiting mesenchymal-to-epithelial transition
M Pliatska, M Kapasa, A Kokkalis… - … and cellular biology, 2018 - Taylor & Francis
Transcription factor-induced reprogramming of somatic cells to pluripotency is mediated via
profound alterations in the epigenetic landscape. The histone variant macroH2A1 (mH2A1) …
profound alterations in the epigenetic landscape. The histone variant macroH2A1 (mH2A1) …
[HTML][HTML] Phylogenetic and regulatory region analysis of Wnt5 genes reveals conservation of a regulatory module with putative implication in pancreas development
M Kapasa, S Arhondakis, S Kossida - Biology direct, 2010 - Springer
Background Wnt5 genes belong to the large Wnt family, encoding proteins implicated into
several tumorigenic and developmental processes. Phylogenetic analyses showed that Wnt5 …
several tumorigenic and developmental processes. Phylogenetic analyses showed that Wnt5 …
[HTML][HTML] Towards the elucidation of the regulatory network guiding the insulin producing cells' differentiation
This study pertains to the regulatory network of neurogenin3 (NGN3, approved symbol:
NEUROG3), the main regulator of insulin producing cells’ formation. In silico regulatory region …
NEUROG3), the main regulator of insulin producing cells’ formation. In silico regulatory region …
Phylogenetic and regulatory region analysis of Wnt5 genes reveals conservation of a regulatory module with putative implication in pancreas development
A Stilianos, K Maria, K Sophia - 2010 - agris.fao.org
Background Wnt5 genes belong to the large Wnt family, encoding proteins implicated into
several tumorigenic and developmental processes. Phylogenetic analyses showed that Wnt5 …
several tumorigenic and developmental processes. Phylogenetic analyses showed that Wnt5 …
Activin-A is a critical inducer of human CD4+ ICOS+ IL-10-secreting regulatory T cells that suppress allergen-driven T cell responses in vitroand experimental asthma …
…, T Brodie, N Poulos, K Samitas, M Kapasa… - 2015 - Eur Respiratory Soc
Introduction: Regulatory T cells (Tregs) are essential for the maintenance of airway tolerance.We
have shown that activin-A induces mouse Tregs that protect from asthma in vivo. Still, …
have shown that activin-A induces mouse Tregs that protect from asthma in vivo. Still, …
Erratum: Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α-dependent pathways …
…, A Manousopoulou, M Kapasa… - Proceedings of the …, 2020 - pure.johnshopkins.edu
The authors note that an additional affiliation should be listed for Federica Sallusto. The new
affiliation should appear as Institute for Research in Biomedicine, Università della Svizzera …
affiliation should appear as Institute for Research in Biomedicine, Università della Svizzera …
[HTML][HTML] The effect of RANKL/OPG balance on reducing implant complications
Despite the phenomenal success of implants particularly in the realms of dentistry and
orthopaedics, there are still challenges to overcome. The failure of implants resulting from infection…
orthopaedics, there are still challenges to overcome. The failure of implants resulting from infection…
Gene regulatory networks and the evolution of animal body plans
EH Davidson, DH Erwin - Science, 2006 - science.org
Development of the animal body plan is controlled by large gene regulatory networks (GRNs),
and hence evolution of body plans must depend upon change in the architecture of …
and hence evolution of body plans must depend upon change in the architecture of …