Acute respiratory distress syndrome (ARDS) is a common disease entity in critical care medicine
and is still associated with a high mortality. Because of the heterogeneous character of …

Social stress is prevalent in many facets of modern society. Epidemiological data suggest that
stress is linked to the development of overweight, obesity and metabolic disease. Although …

Introduction Results from clinical studies have provided evidence for the importance of
leukocyte-endothelial interactions in the pathogenesis of pulmonary diseases such as acute lung …

Scope Metabolic flexibility is the ability to switch metabolism between carbohydrate oxidation
(CHO) and fatty acid oxidation (FAO) and is a biomarker for metabolic health. The effect on …

The human population has slowly transformed from the “hunter–gatherer” period to the
current environment of high energy consumption, minimal physical activity and a lifestyle that …

Background Loss of integrity of the epithelial and endothelial barriers is thought to be a
prominent feature of ventilator-induced lung injury (VILI). Based on its function in vascular …

Nicotinamide riboside (NR) is a nicotinamide adenine dinucleotide (NAD + ) precursor
vitamin. The scarce reports on the adverse effects on metabolic health of supplementation with …

Background. Mechanical ventilation (MV) has the potential to initiate ventilator-induced lung
injury (VILI). The pathogenesis of VILI has been primarily studied in animal models using …

Background Ventilator–induced lung injury (VILI) is characterized by vascular leakage and
inflammatory responses eventually leading to pulmonary dysfunction. Vascular endothelial …

Introduction Uric acid released from injured tissue is considered a major endogenous
danger signal and local instillation of uric acid crystals induces acute lung inflammation via …