HIV-1 and related viruses require co-receptors, in addition to CD4, to infect target cells. The
chemokine receptor CCR-5 (ref. 1) was recently demonstrated to be a co-receptor for …

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

Here, we show that the β-chemokine receptor CKR-5 serves as a cofactor for M-tropic HIV
viruses. Expression of CKR-5 with CD4 enables nonpermissive cells to form syncytia with cells …

THE ORL 1 receptor, an orphan receptor whose human 1 and murine 2-8 complementary
DNAs have recently been characterized, structurally resembles opioid receptors and is …

Natural peptides displaying agonist activity on the orphan G protein-coupled receptor GPR54
were isolated from human placenta. These 54-, 14,- and 13-amino acid peptides, with a …

Short chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are produced
at high concentration by bacteria in the gut and subsequently released in the bloodstream. …

The function of the central cannabinoid receptor (CB 1 ) was investigated by invalidating its
gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of …

Selective PCR amplification of human and mouse genomic DNAs with oligonucleotides
encoding highly conserved regions of the δ-opioid and somatostatin receptors generated a …

Dendritic cells (DCs) and macrophages are professional antigen-presenting cells (APCs)
that play key roles in both innate and adaptive immunity. ChemR23 is an orphan G protein–…

Adenosine is released from metabolically active cells by facilitated diffusion, and is generated
extracellularly by degradation of released ATP. It is a potent biological mediator that …